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Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Chao Liu, Jiaming Li, Ji Sung Park, Samuel M. Hoenig, Marco Barone, Airi Furui, Andrea Mattevi & Brian B. Liau Nat Commun 16 , 3156 (2025). [link] Chromatin modifiers often work in concert with transcription factors (TFs) and other complex members, where they can serve both enzymatic and scaffolding functions.
A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% -- more than any other known intervention.
A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a new study.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
FRIDAY, April 4, 2025 -- Antidepressants appear to increase peoples risk of sudden cardiac death, a new study says.People taking the mood meds are more likely to die suddenly from heart problems, and their risk rises the longer theyre on the dru.
Isocitrate dehydrogenase (IDH) is a key metabolic enzyme that catalyzes the conversion of isocitrate to -ketoglutaric acid (-KG). At present, there are few studies on the drug resistance of mIDH1 inhibitors. Therefore, this article first summarizes terms of IDH1 function from the molecular mechanism of IDH1, the mechanism of mutation, and the metabolism of substances due to mutations.
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Isocitrate dehydrogenase (IDH) is a key metabolic enzyme that catalyzes the conversion of isocitrate to -ketoglutaric acid (-KG). At present, there are few studies on the drug resistance of mIDH1 inhibitors. Therefore, this article first summarizes terms of IDH1 function from the molecular mechanism of IDH1, the mechanism of mutation, and the metabolism of substances due to mutations.
Lszl Petri, Ronen Gabizon, Gyrgy G. Ferenczy, Nikolett Pczka, Attila Egyed, Pter brnyi-Balogh, Tams Takcs, and Gyrgy M. Keser Journal of Medicinal Chemistry 2025 68 (6), 6616-6632 DOI: 10.1021/acs.jmedchem.5c00017 Labeling proteins with covalent ligands is finding increasing use in proteomics applications, including identifying nucleophilic residues amenable for labeling and in the development of targeted covalent inhibitors (TCIs).
The Swiss drugmaker, which holds European rights to Elevidys, suspended three trials while researchers investigate the death of a young man who died following treatment.
TUESDAY, April 2, 2025 -- The shingles vaccine can do more than protect seniors from painful, blistering rashes. It also appears to protect older folks from dementia, researchers say. Seniors who got the shingles vaccine when it became available.
A multi-objective optimization algorithm incorporating the strategies of dynamic semi-parameter adaptation updating, gradient enhancement, and population size reduction is adopted to solve the problem of protein-ligand docking. ABSTRACT Molecular docking, which simulates the binding pose of a drug molecule to target proteins and predicts the binding affinity, is an important computational tool in structure-based drug discovery.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
David Liu receives Breakthrough Prize in Life Sciences By Corie Lok April 5, 2025 Breadcrumb Home David Liu receives Breakthrough Prize in Life Sciences Liu is honored for the development of base editing and prime editing, two gene editing technologies transforming medicine. By Broad Communications April 5, 2025 Credit: Casey Atkins David Liu is a core member at the Broad Institute where he is the Richard Merkin Professor and director of the Merkin Institute for Transformative Technologies in He
A 'weekend warrior' approach to physical activity -- getting 150 minutes of moderate-to-vigorous physical activity over one to two days instead of throughout the week -- improved health and lowered the risk of death, finds a new stud.
THURSDAY, April 3, 2025 -- Health experts are warning that whooping cough, also known as pertussis, is making a dangerous comeback. Cases are rising across the country, and Louisiana recently reported that two infants have died -- the state’s.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
By Dr. Naomi Lowy, Principal Drug Regulatory Expert Trade and national press have reported that recent changes in FDA staffing levels have already led to slower responses to calls and emails. According to reports, which were published before the most recent reports of HHS staff level reductions and tumultuous changes in leadership, FDA staff were missing minor deadlines.
Suzetrigine CAS 2649467-58-1 Weight Average: 473.4 Monoisotopic: 473.137396951 Chemical Formula C 21 H 20 F 5 N 3 O 4 FDA 1/30/2025, Journavx To treat moderate to severe acute pain Press Release 2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]- 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5- dimethyl-5-(trifluoromethyl)oxolane-2- carboxamido]pyridine-2-carboxamide 4-[(2R,3S,4S,5R)-3-(3,4-difluor
In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
MONDAY, March 31, 2025 -- Use of cutting-edge weight-loss drugs like Ozempic and Zepbound has increased dramatically among people with type 1 diabetes, raising safety concerns among experts, a new study says.Both adults and children with type 1.
ABSTRACT Diketopiperazines (DKPs) have emerged as promising candidates for treating diverse diseases, particularly cancer. In this context, 2,5-diketopiperazines have been extensively investigated in comparison with 2,6-diketopiperazines. This work explores the selectivity and impact of 2,6-diketopiperazine enantiomers derived from -amino acids on MDA-MB-231 triple-negative breast cancer cells (TNBC).
Keystone Symposia convened a panel of global health experts to discuss how, as a conference organization, we can extend the reach and impact of our conferences to improve human health worldwide.
New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer's disease over time.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
MONDAY, March 31, 2025 -- A top vaccine official at the U.S. Food and Drug Administration (FDA) is stepping down, warning that vaccine misinformation is coloring the countrys top health decisions.Dr. Peter Marks, director of the FDAs Center for Bi.
| Project Optimus is changing the landscape of oncology drug development by redefining dose optimization standards. Learn how sponsors can align with FDA expectations and implement more precise dose-finding strategies. Watch the full interview with Alex MacDonald now!
The sweeping workforce reduction that began Tuesday was made worse by mistakes and poor communication, including directions for some CMS employees to contact a director who died last year.
FRIDAY, April 4, 2025 -- The U.S. Food and Drug Administration (FDA) has delayed the full approval of Novavaxs COVID-19 vaccine. The decision had been expected by April 1, but the agency now says it needs more information before moving forward.The.
Navigating a Shifting Regulatory Landscape On Thursday, March 27, 2025, HHS announced that they would be conducting a reduction in force impacting nearly 3,500 full time FDA employees nearly 20% of the Agencys entire workforce. This comes on the tail end of a layoff in February of this year, when about 700 FDA employees were terminated.
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