Trending Articles

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Fish Oil Supplements Might Help Prevent Cancer

Drugs.com

TUESDAY, Nov. 5, 2024 -- The omega-3 and omega-6 fatty acids in fish oil supplements might help protect people from cancer, a new study claims.Study participants with higher levels of omega-3s had lower rates of colon, stomach, lung and other.

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Cancer cell therapy from Arcellx, Gilead shows promise in early data

BioPharma Drive: Drug Pricing

The companies’ CAR-T seemed to cause fewer movement disorders in a multiple myeloma trial than J&J's Carvykti has in other tests, although Wall Street analysts were divided on how the two drugs compare.

Therapies 113
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A Comprehensive Analysis on Galantamine Based Hybrids for the Management of Alzheimer's Disease

Chemical Biology and Drug Design

Alzheimer's disease (AD) is a progressive age-related neurodegenerative brain disorder that destroys memory and other important mental functions. This review article comprehensively summarized the recent advancements in galantamine and its hybrid analogs as potential therapeutic agents for the management of AD. Furthermore, we also provided the design, synthesis, and SAR analysis of the galantamine-based compounds used in the last decades for the management of AD.

Disease 100
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Preclinical Evaluation of MK-8189: A Novel Phosphodiesterase 10A Inhibitor for the Treatment of Schizophrenia [Neuropharmacology]

ASPET

MK-8189 is a novel phosphodiesterase 10A (PDE10A) inhibitor being evaluated in clinical studies for the treatment of schizophrenia. PDE10A is a cyclic nucleotide phosphodiesterase enzyme highly expressed in medium spiny neurons of the striatum. MK-8189 exhibits sub-nanomolar potency on the PDE10A enzyme and has excellent pharmaceutical properties. Oral administration of MK-8189 significantly increased cGMP and pGluR1 in rat striatal tissues.

Treatment 100
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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High Throughput AI-Driven Drug Discovery Pipeline

Nvidia Developer: Drug Discovery

The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional. The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional methods are often time-consuming and costly, with the process of bringing a new drug to market taking up to 15 years and costing between $1–2B.

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Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

Science Daily: Pharmacology News

Children who experienced sugar restrictions during their first 1,000 days after conception had up to 35% lower risk of developing type 2 diabetes and as much as 20% less risk of hypertension as adults. The researchers used contemporary data from the U.K. Biobank, a database of medical histories and genetic, lifestyle and other disease risk factors, to study the effect of those early-life sugar restrictions on health outcomes of adults conceived in the U.K. just before and after the end of wartim

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Why Treatments Can Fail Folks With 'Wet' Macular Degeneration -- and What Might Really Work

Drugs.com

TUESDAY, Nov. 5, 2024 -- Current treatments sometimes fail to help people with “wet” age-related macular degeneration -- and researchers now think they know why.Wet AMD is caused by an overgrowth of blood vessels in the retina, the light-sensing tis.

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Sickle cell patient dies in Beam study of base editing therapy

BioPharma Drive: Drug Pricing

The death, which investigators linked to a preparatory chemo treatment rather than Beam's medicine, highlights the risks of using decades-old transplant drugs alongside cutting-edge CRISPR medicines.

Therapies 105
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Organoids: the versatile platform for discovery and regeneration

Drug Target Review

Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first. Further still, think about implanting these mini organs into the patient to restore lost function.

Treatment 105
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Large meltwater accumulation revealed inside Greenland Ice Sheet

Science Daily: Pharmacology News

A new study unveils a surprising discovery: a substantial amount of meltwater is temporarily stored within the Greenland Ice Sheet during summer months. For the first time, an international group of researchers was able to quantify meltwater with positioning data. The finding challenges current models of how ice sheets contribute to global sea level rise.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Strategies for effective biosimilar risk management plans

Drug Patent Watch

The development and approval of biosimilars have become increasingly important in the biopharmaceutical industry, offering cost-effective alternatives to original biological medicines. However, biosimilars pose unique challenges in terms of risk management due to their complex nature and potential for immunogenicity.

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In a National First, an Idaho Health Department Is Refusing to Give COVID Vaccines

Drugs.com

MONDAY, Nov. 4, 2024 -- In what may be a first for the United States, a regional public health department in Idaho will no longer provide COVID-19 vaccines, following a close vote by its board.“I’m not aware of anything else like this,” said Adria.

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Novo, with new results, to seek approval for obesity drug in MASH

BioPharma Drive: Drug Pricing

The Phase 3 findings position semaglutide to become the first drug of its kind for the liver disease. But they also confirm GLP-1s aren't a "silver bullet" for MASH, one analyst argued.

Drugs 109
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Production of Virus in Insect Versus Mammalian Cells

addgene Blog

Pre-made viruses have become increasingly accessible and are useful for saving time and avoiding potentially costly set-ups. However, there are many cases where the specific viral particles you need are not available, or the cost of custom viruses are too high for your budget. In those cases, you’ll need to produce your viruses in-house.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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One of the fastest-spinning stars in the Universe

Science Daily: Pharmacology News

New research in our Milky Way has revealed a neutron star that rotates around its axis at an extremely high speed. It spins 716 times per second, making it one of the fastest-spinning objects ever observed.

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A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity

Broad Institute

A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity By Corie Lok November 4, 2024 Breadcrumb Home A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease brings together Danish and Broad scientists.

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Too Many Meds: 'Polypharmacy' Can Really Harm Alzheimer's Patients

Drugs.com

MONDAY, Nov. 4, 2024 -- Alzheimer’s disease patients prescribed fistfuls of daily drugs are at greater risk of harm, a new study warns.Patients with Alzheimer’s prescribed five or more daily medications suffer from more symptoms, falls and hos.

Disease 105
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Novo takes big step toward ending Ozempic, Wegovy shortages

BioPharma Drive: Drug Pricing

All doses of the two drugs are now listed as available in the U.S., per an FDA database, although the company cautioned patients may still experience "variability" filling their prescriptions.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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How Field Reimbursement Services Help Overcome Coverage Barriers and Improve Patient Outcomes

Drug Channels

Today’s guest post comes from Kimberley Chiang, Vice President of Biopharma Commercial Solutions at CoverMyMeds Kimberley highlghts the crucial roles of field reimbursement managers in removing access and reimbursement barriers. She then identifies the keys to successful implementation of field reimbursement services. To learn more, register for CoverMyMeds' November 13, 2024, webinar: Specialty Therapies & Field Reimbursement Services: Driving Better Outcomes for Brands and Patients.

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Synthetic genes engineered to mimic how cells build tissues and structures

Science Daily: Pharmacology News

Researchers have developed synthetic genes that function like the genes in living cells. The artificial genes can build intracellular structures through a cascading sequence that builds self-assembling structures piece by piece. The discovery offers a path toward using a suite of simple building blocks that can be programmed to make complex biomolecular materials, such as nanoscale tubes from DNA tiles.

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NIOSH-developed Tools for Monitoring Respirable Crystalline Silica in the Mining Environment

NIOSH Science Blog: Drugs

Respirable crystalline silica (RCS), most commonly in the form of quartz, is a known health hazard in many industries. Exposure to RCS can lead to debilitating and incurable diseases. To minimize the risk of health effects associated with exposure, the Mine Safety and Health Administration (MSHA) released a final rule for lowering miners’ exposure to RCS in April 2024.

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Diabetes Can Damage Your Eyes' Retinas: An Expert Explains

Drugs.com

TUESDAY, Nov. 5, 2024 -- People with diabetes face a number of health challenges related to their chronic condition, and loss of vision due to retinal damage is one of them.“Diabetes can silently damage a person’s most precious sense, their sight, b.

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A new biotech, built around protein design, springs from David Baker’s lab

BioPharma Drive: Drug Pricing

Archon Biosciences, co-founded by the winner of the 2024 Nobel Prize in Chemistry, emerged from stealth Wednesday with $20 million in seed capital.

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Handling Drug Patent Abandonment: Opportunities and Challenges

Drug Patent Watch

The pharmaceutical industry is known for its complex regulatory environment and lengthy product development processes. One often overlooked aspect of this industry is the potential benefits of abandoned and expired patents. These patents can provide opportunities for companies to bring new products to market at a lower cost and with reduced development time.

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Bio-based fibers could pose greater threat to the environment than conventional plastics

Science Daily: Pharmacology News

New research has shown that bio-based fibers caused higher mortality, and reduced growth and reproductivity, among earthworms -- a species critical to the health of soils globally -- than conventional plastics. It has led scientists to suggest that materials being advocated as alternatives to plastic should be tested thoroughly before they are used extensively in a range of products.

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From the Porcine to the Ridiculous to the Court of Appeals: Phibro’s Suit Against FDA Gets Muddy

FDA Law Blog: Biosimilars

By Sara W. Koblitz & Charles D. Snow & Karla L. Palmer & John W.M. Claud — As we reported back in January, Phibro Animal Health Corporation challenged FDA’s decision to remove a drug called carbadox—used as an antimicrobial drug to treat gastrointestinal disease in food-producing pigs—from the market. More specifically, FDA rescinded approval of a “regulatory method” that Phibro used to establish that carbadox is safe and effective.

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Mindfulness Meditation Could Have Direct Effect in Reducing Pain

Drugs.com

MONDAY, Nov. 4, 2024 -- Many people turn to mindfulness meditation to help them manage their chronic pain, a practice that’s been used for centuries.However, it’s been an open question whether meditation is simply functioning as a placebo, rather th.

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Evommune raises $115M to accelerate immune drug tests

BioPharma Drive: Drug Pricing

The biotech expects three Phase 2 readouts in urticaria and eczema over the next two years, and will keep its “options open” regarding an IPO, its CEO said.

Drugs 104
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Improvements in SureChEMBL's chemistry search and adoption of RDKit

The ChEMBL-og

Dear SureChEMBL users, If you frequently rely on our "chemistry search" feature, today brings great news! We’ve recently implemented a major update that makes your search experience faster than ever. What's New? Last week, we upgraded our structure search engine by aligning it with the core code base used in ChEMBL. This update allows SureChEMBL to leverage our FPSim2 Python package , returning results in approximately one second.

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The secrets of baseball's magic mud

Science Daily: Pharmacology News

The unique properties of baseball's famed 'magic' mud, which MLB equipment managers applied to every ball in the World Series, have never been scientifically quantified -- until now. Researchers now reveal what makes the magic mud so special.

Research 101
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As Jurisprudence Under Loper Bright Develops, Early Scorecard is Mixed

FDA Law Blog: Biosimilars

By John W.M. Claud & Sara W. Koblitz & JP Ellison — Back in July, the United States Supreme Court turned the world of administrative law on its head, adding new layers of judicial oversight to what might have previously been thought of as fairly non-descript Federal agency functions. One of those cases was Loper Bright v. Raimondo , which formally overruled the 40-year precedent under Chevron , under which courts gave agencies deference when interpreting statutory ambiguity.

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Too Much Sitting Harms the Heart, Even in Folks Who Exercise

Drugs.com

MONDAY, Nov. 4, 2024 -- There's just something about sitting.New research shows that too much time on sofas and chairs harms the heart -- even among people who get the minimum recommended amount of daily exercise.“Taking a quick walk after work may.

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GSK vaccine sales sink on lower demand for RSV, shingles shots

BioPharma Drive: Drug Pricing

The British pharma’s experience during the third quarter mirrored that of rival Pfizer, which also reported lower sales of its competing RSV shot.

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