Trending Articles

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Study strengthens link between shingles vaccine and lower dementia risk

Science Daily: Pharmacology News

A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% -- more than any other known intervention.

Vaccine 311
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Size-Dependent Target Engagement of Covalent Probes

Covalent Modifiers

Lszl Petri, Ronen Gabizon, Gyrgy G. Ferenczy, Nikolett Pczka, Attila Egyed, Pter brnyi-Balogh, Tams Takcs, and Gyrgy M. Keser Journal of Medicinal Chemistry 2025 68 (6), 6616-6632 DOI: 10.1021/acs.jmedchem.5c00017 Labeling proteins with covalent ligands is finding increasing use in proteomics applications, including identifying nucleophilic residues amenable for labeling and in the development of targeted covalent inhibitors (TCIs).

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Highly accurate blood test diagnoses Alzheimer's disease, measures extent of dementia

Science Daily: Pharmacology News

A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a new study.

Disease 319
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Cell, gene therapy makers lose a champion at FDA with exit of Peter Marks

BioPharma Drive: Drug Pricing

Marks’ resignation leaves the field without a regulator many view as “integral” to its progress over the last decade.

Therapies 315
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Shingles Vaccine Protects Against Dementia

Drugs.com

TUESDAY, April 2, 2025 -- The shingles vaccine can do more than protect seniors from painful, blistering rashes. It also appears to protect older folks from dementia, researchers say. Seniors who got the shingles vaccine when it became available.

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Peter Marks, FDA’s top vaccine official, resigns

BioPharma Drive: Drug Pricing

In his resignation letter, Marks cited disagreement with HHS Secretary Robert F. Kennedy Jr., who he said pushed “misinformation and lies.

Vaccine 307
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More Uncertainty and Less Advice from FDA Means Companies will Need to Even More Carefully Chart their own Course to Achieve their Goals

FDA Law Blog: Biosimilars

By Dr. Naomi Lowy, Principal Drug Regulatory Expert Trade and national press have reported that recent changes in FDA staffing levels have already led to slower responses to calls and emails. According to reports, which were published before the most recent reports of HHS staff level reductions and tumultuous changes in leadership, FDA staff were missing minor deadlines.

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Measles Outbreak Leads to Dangerous Vitamin A Toxicity

Drugs.com

FRIDAY, March 28, 2025 -- As a measles outbreak spreads across U.S., doctors are now seeing a new and unexpected danger: Children getting sick from taking too much vitamin A.At Covenant Childrens Hospital in Lubbock, Texas, several unvaccinated c.

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Suzetrigine

New Drug Approvals

Suzetrigine CAS 2649467-58-1 Weight Average: 473.4 Monoisotopic: 473.137396951 Chemical Formula C 21 H 20 F 5 N 3 O 4 FDA 1/30/2025, Journavx To treat moderate to severe acute pain Press Release 2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]- 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5- dimethyl-5-(trifluoromethyl)oxolane-2- carboxamido]pyridine-2-carboxamide 4-[(2R,3S,4S,5R)-3-(3,4-difluor

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Cold plunges actually change your cells

Science Daily: Pharmacology News

Cold water immersion for seven days significantly improves cellular resilience and autophagic function, helping cells manage stress better. This adaptation could enhance health and longevity, potentially preventing diseases and slowing aging at a cellular level.

Disease 305
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Lilly hits same Alzheimer’s roadblock in Europe as Eisai, Biogen

BioPharma Drive: Drug Pricing

Key regulators are not recommending Lilly’s Kisunla be cleared for the European market. The company says it plans to appeal the verdict, a strategy successfully employed by Eisai.

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Selective Antiproliferative and Apoptotic Effects of 2,6‐Diketopiperazines on MDA‐MB‐231 Triple‐Negative Breast Cancer

Chemical Biology and Drug Design

ABSTRACT Diketopiperazines (DKPs) have emerged as promising candidates for treating diverse diseases, particularly cancer. In this context, 2,5-diketopiperazines have been extensively investigated in comparison with 2,6-diketopiperazines. This work explores the selectivity and impact of 2,6-diketopiperazine enantiomers derived from -amino acids on MDA-MB-231 triple-negative breast cancer cells (TNBC).

Disease 100
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More Type 1 Diabetics Are Obese, Taking GLP-1 Drugs

Drugs.com

MONDAY, March 31, 2025 -- Use of cutting-edge weight-loss drugs like Ozempic and Zepbound has increased dramatically among people with type 1 diabetes, raising safety concerns among experts, a new study says.Both adults and children with type 1.

Drugs 277
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Keystone Symposia Aims to Increase Global Impact-- Experts Weigh in on Strategy

keypoint

Keystone Symposia convened a panel of global health experts to discuss how, as a conference organization, we can extend the reach and impact of our conferences to improve human health worldwide.

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Being physically active, even just a couple of days a week, may be key to better health

Science Daily: Pharmacology News

A 'weekend warrior' approach to physical activity -- getting 150 minutes of moderate-to-vigorous physical activity over one to two days instead of throughout the week -- improved health and lowered the risk of death, finds a new stud.

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Roche halts testing of Sarepta Duchenne gene therapy in Europe

BioPharma Drive: Drug Pricing

The Swiss drugmaker, which holds European rights to Elevidys, suspended three trials while researchers investigate the death of a young man who died following treatment.

Therapies 270
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The Nobel Duel

Codon

A cautionary tale about the competitive pressures of scientific research, and how they alter the course of history.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Top FDA Vaccine Official Quits, Warns of Vaccine Misinformation

Drugs.com

MONDAY, March 31, 2025 -- A top vaccine official at the U.S. Food and Drug Administration (FDA) is stepping down, warning that vaccine misinformation is coloring the countrys top health decisions.Dr. Peter Marks, director of the FDAs Center for Bi.

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Project Optimus: Transforming Dose Optimization in Oncology Drug Development

Fierce BioTech

| Project Optimus is changing the landscape of oncology drug development by redefining dose optimization standards. Learn how sponsors can align with FDA expectations and implement more precise dose-finding strategies. Watch the full interview with Alex MacDonald now!

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Retinal therapy may restore lost vision

Science Daily: Pharmacology News

Researchers have successfully developed a novel drug to restore vision. The treatment method restores vision through retinal nerve regeneration.

Therapies 288
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FDA official’s ouster sends shares of vaccine makers sliding

BioPharma Drive: Drug Pricing

Shares in Moderna, Vaxcyte, Novavax and BioNTech all fell Monday after Peter Marks, head of the FDA office that reviews vaccines, resigned on Friday.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The Impact of FDA Layoffs on Medical Device Developers

thought leadership

Navigating a Shifting Regulatory Landscape On Thursday, March 27, 2025, HHS announced that they would be conducting a reduction in force impacting nearly 3,500 full time FDA employees nearly 20% of the Agencys entire workforce. This comes on the tail end of a layoff in February of this year, when about 700 FDA employees were terminated.

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Two Louisiana Infants Die of Whooping Cough Amid Drop in Vaccinations

Drugs.com

THURSDAY, April 3, 2025 -- Health experts are warning that whooping cough, also known as pertussis, is making a dangerous comeback. Cases are rising across the country, and Louisiana recently reported that two infants have died -- the state’s.

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Why PDUFA VII User Fees Are on the Rise in 2025

DS in Pharmatics

The Prescription Drug User Fee Act (PDUFA) has been a cornerstone of the U.S. Food and Drug Administrations (FDA) drug approval process since its inception in 1992.

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New study links lower proportions of certain sleep stages to brain changes associated with Alzheimer's disease

Science Daily: Pharmacology News

New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer's disease over time.

Disease 264
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How discoverable, comparable and explorable is your data?

BioPharma Drive: Drug Pricing

Accelerate biomarker research with high-quality, expert-curated data to drive precision medicine.

Research 246
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Navigating the Impact of New Tariffs: Strategies for Success Amidst Recent Trade Policy Changes

thought leadership

The US Government recently modified their policy to utilize tariffs to in an effort to support the US economy. Pharmaceutical tariffs have been announced causing many global organizations to investigate the consequences of the tariffs on their overall product portfolio. Companies need to know the facts and have data to support their decisions.

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Citrus Oil Formula May Relieve Dry Mouth for Cancer Patients

Drugs.com

SATURDAY, March 29, 2025 -- A new formula made with natural citrus oil could help cancer patients find relief from dry mouth, a common and painful side effect of radiation treatments.The formula was created by researchers at the University of South.

Research 270
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BLA vs. NDA: What’s the Difference?

DS in Pharmatics

Navigating the regulatory pathways for drug approvals in the U.S. can be complex, especially when determining whether a Biologics License Application (BLA) or a New Drug Application (NDA) is the appropriate route.