Drug Discovery Today
OCTOBER 15, 2024
Pioneer Group, the specialist life science infrastructure and venture-building company, welcomed 425 school children from 29 schools to eight of its sites across the UK last week to mark Ada Lovelace Day, an international celebration of the achievements of women in STEM.
Chemical Biology and Drug Design
OCTOBER 13, 2024
This review will provide a comprehensive analysis and outlines various state-of-the-art AI/ML techniques to the readers with their framework applications. This review also highlights the challenges in this field which need to be addressed for further successes in pharmaceutical applications. ABSTRACT The technological revolutions in computers and the advancement of high-throughput screening technologies have driven the application of artificial intelligence (AI) for faster discovery of drug mole
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Practical Cheminformatics
OCTOBER 8, 2024
“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.
Science Daily: Pharmacology News
OCTOBER 10, 2024
Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
OCTOBER 11, 2024
FRIDAY, Oct. 11, 2024 -- Endometriosis could be linked to the health of a woman’s microbiome, a new study says. The discovery might help lead to an early test for the painful condition, and possible new treatments.A specific set of bacteria in w.
ASPET
OCTOBER 8, 2024
Amitriptyline, a pleiotropic tricyclic antidepressant, possesses anti-oxidant and anti-inflammatory properties. Despite its diverse benefits, the specific effects of amitriptyline on IBD are not yet well defined. To explore this, we utilized a DSS-induced colitis model to examine the anti-inflammatory effects of amitriptyline and the underlying mechanisms by which it operates.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Perficient: Drug Development
OCTOBER 11, 2024
In our ongoing Health and Life Sciences series, we’re excited to share a remarkable transformation achieved by a leading pediatric health system. This organization, renowned for its commitment to children’s health, faced challenges in scaling its outreach efforts and enhancing patient experiences. Here’s how Perficient helped revolutionize their approach using Salesforce solutions.
Science Daily: Pharmacology News
OCTOBER 9, 2024
Studying microscopic layers of dirt dug from the Tam Pa Ling cave site in northeastern Laos has provided a team of archaeologists further insights into some of the earliest evidence of Homo sapiens in mainland Southeast Asia. The site, which has been studied for the past 14 years, has produced some of the earliest fossil evidence of our direct ancestors in Southeast Asia but now a new study has reconstructed the ground conditions in the cave between 52,000 and 10,000 years ago.
Drugs.com
OCTOBER 10, 2024
THURSDAY, Oct. 10, 2024 -- After Hurricane Helene knocked out a North Carolina production plant for a major supplier of IV fluids for U.S. hospitals, officials said the federal government is reaching out internationally to help restore supply.The.
ASPET
OCTOBER 8, 2024
Discoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enhanced in various disease conditions. Although previous research suggests that DDR1 contributes to renal disease progression, DDR1 inhibitors for renal fibrosis have yet to be developed. In this study, we used unilateral ureteral obstruction (UUO) mice to investigate whether CH6824025, a strong and selective DDR1 phosphorylation inhibitor, can improve renal fibrosis.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
OCTOBER 10, 2024
In a letter to Pfizer’s board, the activist investor claimed former CEO Ian Read and CFO Frank D’Amelio were pressured to abandon a Starboard-led attempt to change the company’s direction.
Drug Channels
OCTOBER 11, 2024
Today’s guest post comes from Angie Franks, Chief Executive Officer of Kalderos. Angie discusses how the Maximum Fair Price provision of the Inflation Reduction Act of 2022 will challenge providers, pharmacies, and manufacturers. She explains how Kalderos’ Truzo platform could reduce duplicate claims and address compliance issues. To learn more, register for Kalderos’ October 25 webinar Cracking the MFP Code: How Flexible Technology Helps You Navigate an Evolving Landscape.
Science Daily: Pharmacology News
OCTOBER 10, 2024
A new study from The Neuro (Montreal Neurological Institute-Hospital) of McGill university, the University of Ottawa and the University of Zaragoza in Spain elaborates on bilingualism's role in cognition, showing increased efficiency of communication between brain regions.
Drugs.com
OCTOBER 10, 2024
THURSDAY, Oct. 10, 2024 -- More than 15.5 million U.S. adults have been diagnosed with ADHD, and nearly three-quarters of those taking medication to treat it say drug shortages are hampering their ability to get help, a new report finds. According.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
ASPET
OCTOBER 8, 2024
Progressive multiple sclerosis (PMS) represents the worsening phase of the disease by accumulative neurodegeneration and disability, mainly refractory to current treatments. The therapeutic options remain challenging based partially on the lack of understanding of the pathogenic mechanisms but also because the early dogma was centered on neuroinflammation, overshadowing the critical role of the tissue repair process.
Perficient: Drug Development
OCTOBER 9, 2024
Today’s digital landscape is dynamic. It favors speed over size, agility over efficiency, and cross-functional collaboration over rigid structures. You must be prepared to adapt and scale your teams as priorities shift. Moving forward requires a comprehensive digital strategy that outlines the capabilities, agility, and alignment needed to stay ahead of digital disruption.
BioPharma Drive: Drug Pricing
OCTOBER 9, 2024
Many pharma companies are now using de-identified lab data to identify potential patients and their physicians in time to impact the patient’s treatment plan. In this Q&A, learn how lab data can be used to increase patient access.
Science Daily: Pharmacology News
OCTOBER 10, 2024
Skin pigmentation may act as a 'sponge' for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report.
Drugs.com
OCTOBER 9, 2024
WEDNESDAY, Oct. 9, 2024 -- When it comes to coverage for the pricey GLP-1 weight-loss drugs Wegovy and Zepbound, only a fifth of large U.S. companies cover the medications in their health insurance plans, a new survey shows. In a report published.
ASPET
OCTOBER 8, 2024
Androgen deprivation is the standard treatment for prostate cancer (PCa) patients. However, the disease eventually progresses as castration-resistant PCa (CRPC). Enzalutamide, an AR inhibitor, is a typical drug to treating CRPC and due to continuous reliance on the drug, can lead to Enzalutamide-resistance (ENZ-r). This highlights the necessity for developing novel therapeutic targets to combat the gain of resistance.
Codon
OCTOBER 13, 2024
Xander Balwit , editor-in-chief of Asimov Press, writes about a restaurant that is bullish on GMOs and other food technology for Issue 04. When one considers the millions of permutations of foods and wines to test, it is easy to see that life is too short for the formulation of dogma. — A.J. Liebling, In Between Meals The facade of Farma in San Francisco.
Drug Patent Watch
OCTOBER 8, 2024
A recent study published in Drug Discovery Today highlights the potential of artificial intelligence (AI) in revolutionizing drug discovery and development processes[1]. The research, conducted by a team from the University of Cambridge and AstraZeneca, explores how AI can be leveraged to enhance various aspects of pharmaceutical research, from target identification to clinical trials.
Science Daily: Pharmacology News
OCTOBER 9, 2024
Microbiologists found that showerheads and toothbrushes are teeming with an extremely diverse collection of viruses -- most of which have never been seen before.
Drugs.com
OCTOBER 8, 2024
TUESDAY, Oct. 8, 2024 -- "Black Box” warnings added to antidepressants might have contributed to an increase in suicide attempts and deaths among young people, a new evidence review claims.The warnings say that antidepressants might be associated w.
ASPET
OCTOBER 8, 2024
The objective of this study is to investigate whether PI3kinase (PI3K) and p38 mitogen-activated kinase contributes to the protection of irisin during hemorrhage/resuscitation. Experimental groups were divided by receiving the different treatments during resuscitation: I ) Hemorrhage: Adult male CD-1 mice were subjected to hemorrhage at a mean arterial blood pressure of 35~45 mmHg for 60 min followed by 120 min of resuscitation (n=13); II ) Hemorrhage + Irisin: receiving irisin (5µg/kg) (n=
NIOSH Science Blog: Drugs
OCTOBER 8, 2024
Workers who respond to roadway emergencies, such as vehicle crashes, can face multiple hazards. Working at roadway incidents frequently exposes responders to potentially being struck by passing motor vehicle traffic leading to serious injury or death. These secondary crashes during responses to roadway incidents contribute to about 50 emergency responder fatalities and injuries annually.[1][2] Additionally, crashes during roadway incident responses can cause extensive property damage to agency e
Drug Channels
OCTOBER 9, 2024
As regular readers of Drug Channels know, U.S. distribution and dispensing channels for prescription drugs are undergoing significant evolution and consolidation as the changing economics of pharmaceuticals challenge conventional business models. During this period of volatility, the core business model of the Big Three public pharmaceutical distribution companies—Cardinal Health, Cencora, and McKesson—remains intact.
Science Daily: Pharmacology News
OCTOBER 9, 2024
Researchers tracked the health of nearly one thousand mice on a variety of diets to see if these diets would extend the mice's lifespan. The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population. By doing so, the results are made more clinically relevant, elevating the study to one of the most significant investigations into aging and lifespan to date.
Drugs.com
OCTOBER 8, 2024
TUESDAY, Oct. 8, 2024 -- The brain has a waste-disposal system that clears away junk proteins that contribute to the development of dementia and Alzheimer’s disease, a new study finds.Advanced imaging scans have revealed a network of fluid-filled s.
ASPET
OCTOBER 8, 2024
Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL fusion protein, such as imatinib (Gleevec), have revolutionized targeted cancer therapies. However, drug resistance and side effects, particularly those affecting hemostasis, continue to pose significant challenges for TKI therapies. As tyrosine kinases serve pivotal roles in platelet hemostatic function, we investigated the potential impact of both established and emerging ABL TKIs on human platelet activities ex vivo.
Drug Patent Watch
OCTOBER 9, 2024
The pharmaceutical industry plays a crucial role in global healthcare, providing essential medications that improve and save lives. Within this industry, generic pharmaceuticals are particularly important due to their affordability and accessibility.
BioPharma Drive: Drug Pricing
OCTOBER 14, 2024
The agency agreed in court to allow compounding companies to continue producing copycat versions of Lilly’s fast-selling medicines while it reevaluates its recent decision to declare the drugs back in supply.
Science Daily: Pharmacology News
OCTOBER 8, 2024
A research team describes how they engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to synthesize artificial chains of TNA, which is inherently more stable than DNA, advances the discovery of potentially more powerful, precise therapeutic options to treat cancer and autoimmune, metabolic and infectious diseases.
Drugs.com
OCTOBER 10, 2024
THURSDAY, Oct. 10, 2024 -- More than a third of women don’t know they are pregnant in time to meet the six-week abortion ban active in four U.S. states, a new study finds.About 37% of women who got an abortion in 2021 and 2022 discovered they were p.
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