Merck opens $1B vaccine plant in North Carolina
BioPharma Drive: Drug Pricing
MARCH 11, 2025
Unveiling of the new factory comes as Merck and other pharma companies face pressure to reshore manufacturing back to the U.S.
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Comprehensive Characterization of Bruton’s Tyrosine KinaseInhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Noncovalent Mechanistic Signatures
Covalent Modifiers
MARCH 16, 2025
Antonia C. Darragh, Andrew M. Hanna, Justin H. Lipner, Alastair J. King, Nicole B. Servant, and Mirza Jahic ACS Pharmacol. Transl. Sci. 2025 [link] Uncovering a drugs mechanism of action and possible adverse effects are critical components in drug discovery and development. Moreover, it provides evidence for why some drugs prove more effective than others and how to design better drugs altogether.
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First operating system for quantum networks
Science Daily: Pharmacology News
MARCH 12, 2025
Researchers have announced the creation of the first operating system designed for quantum networks: QNodeOS. The research marks a major step forward in transforming quantum networking from a theoretical concept to a practical technology that could revolutionize the future of the internet.
Parents Feel They Are Lacking Information About Bird Flu
Drugs.com
MARCH 14, 2025
FRIDAY, March 14, 2025 -- Only 43 percent of parents report they are able to find accurate and current information on avian influenza A(H5N1), commonly known as bird flu, according to the University of Michigan Health C.S. Mott Children's Hospital.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results
Chemical Biology and Drug Design
MARCH 14, 2025
Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins. ABSTRACT Membrane proteins (MPs) are important yet challenging targets for drug discovery.
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Microplastics could be fueling antibiotic resistance
Science Daily: Pharmacology News
MARCH 11, 2025
Researchers were shocked to see that bacteria's antimicrobial resistance is strengthened when exposed to plastic particles and point to a potential outsized impact on refugees.
New technology puts a spatial lens on CRISPR screening
Broad Institute
MARCH 12, 2025
New technology puts a spatial lens on CRISPR screening By Leah Eisenstadt March 12, 2025 Breadcrumb Home New technology puts a spatial lens on CRISPR screening Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells. By Leah Eisenstadt March 12, 2025 Credit: Broad Communications Scientists in the Spatial Technology Platform at the Broad develop, use, and share spatial -omics approaches
NIH Cuts Funding for Studies on Vaccine Hesitancy and Acceptance
Drugs.com
MARCH 11, 2025
TUESDAY, March 11, 2025 -- The National Institutes of Health (NIH) is cutting or canceling more than 40 grants focused on vaccine hesitancy and ways to increase vaccine acceptance, according to an email obtained by The Washington Post.The message .
Pyrrole‐Tethered Bisbenzoxazole Derivatives: Apoptosis‐Inducing Agents Targeting Breast Cancer Cells
Chemical Biology and Drug Design
MARCH 13, 2025
Design and synthesis of pyrrole-tethered bisbenzoxazole (PTB) derivatives reveal potent anticancer activity against MCF-7 breast cancer cells. Compounds B8 , B14 , and B18 exhibit ~20-fold lower IC 50 values than tamoxifen, induce early-stage apoptosis, and arrest the cell cycle at the G1 phase via caspase-9 activation. These findings position PTB derivatives as promising candidates for targeted breast cancer therapy.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Novo’s Wegovy successor disappoints in second large trial
BioPharma Drive: Drug Pricing
MARCH 10, 2025
A study in people with obesity and diabetes again found CagriSema helps people lose weight, but not by enough to clearly surpass Eli Lilly’s Zepbound.
Humans have a long way to go in understanding a dog's emotions
Science Daily: Pharmacology News
MARCH 10, 2025
New research has revealed that people often do not perceive the true meaning of their pet's emotions and can misread their dog. The reasons for this are many and include a human misunderstanding of dog expressions due to a bias towards projecting human emotions onto our pets.
High Throughput Screening (HTS)
Sygnature Discovery
MARCH 14, 2025
Sygnature Discovery offers high throughput screening along with additional hit identification tools including virtual screening, knowledge-based design, and fragment screening. Employing a comprehensive strategy for hit identification, we use the most effective methods to accurately pinpoint hit series that have the highest potential for evolving into compounds with drug-like properties.
Poll Reveals Only 17 Percent Think Medicaid Funding Should Be Cut
Drugs.com
MARCH 12, 2025
WEDNESDAY, March 12, 2025 -- Only 17 percent of adults say they want to see Medicaid funding decreased, while 42 percent think funding should increase and 40 percent think it should be kept about the same, according to results of the February 2025.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Machine Learning‐Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent
Chemical Biology and Drug Design
MARCH 12, 2025
We have discovered a novel non-covalent MurA inhibitor as an antibacterial agent through machine learning and bioactivity testing. This is the first to use machine learning for virtual screening of non-covalent inhibitors of MurA. ABSTRACT The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis.
2seventy bio, Bluebird’s cell therapy spinout, sells to Bristol Myers for less than $300M
BioPharma Drive: Drug Pricing
MARCH 11, 2025
The deal ends 2Seventy’s short run as an independent company, during which it restructured, sold off research and lost nearly all of its market value.
Four tiny planets found orbiting one of our nearest stars
Science Daily: Pharmacology News
MARCH 11, 2025
Astronomers have revealed new evidence that there are not just one but four tiny planets circling around Barnard's Star, the second-nearest star system to Earth.
Recap Of The 2025 CDD Basel Science Community Meeting
Collaborative Drug
MARCH 14, 2025
The 2025 CDD Basel Science Community Meeting brought together researchers, industry experts, and thought leaders to discuss advancements in drug discovery, data management, FAIR data principles, and AI in research.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Common Vaginal Infection Should Be Treated as an STI, Study Says
Drugs.com
MARCH 10, 2025
MONDAY, March 10, 2025 -- A common vaginal infection that affects nearly 1 in 3 women worldwide should be reclassified as a sexually transmitted infection (STI), a new study suggests.Bacterial vaginosis (BV) is now treated as a womens health i.
The impact of biosimilars on biologic drug life cycle management
Drug Patent Watch
MARCH 16, 2025
The Biosimilar Revolution: How It's Changing the Game for Biologic Drug Manufacturers As the pharmaceutical industry continues to evolve, one trend is gaining significant attention: the rise of biosimilars. For those who may be new to this concept, biosimilars are biologic drugs that are highly similar to existing biologic medicines, but at a lower cost.
Beam base editing therapy gets ‘proof of concept’ in rare lung disease
BioPharma Drive: Drug Pricing
MARCH 10, 2025
While initial study results suggest Beam's technology can correct alpha-1 antitrypsin deficiency's genetic roots, shares fell by double digits.
Is red wine a healthier choice than white wine? Uncorking the cancer risks
Science Daily: Pharmacology News
MARCH 10, 2025
Researchers have conducted a study that scours 'the vast and often contradictory literature on the carcinogenicity of red and white wine' to assess whether this assumption holds up, and to compare the cancer risks associated with wine type.
Disabling Cookies in Sitecore SDKs
Perficient: Drug Development
MARCH 12, 2025
Intro In this post, we’ll take a look at a couple Sitecore SDKs commonly used to build XM Cloud head applications. Specifically, we’ll be looking at how to disable cookies used by these SDKs. This can be useful for data privacy and/or regulatory compliance reasons. These SDKs allow your application to integrate with other composable Sitecore services like analytics, personalization, and search.
Small Number of Acne Products Recalled for Problematic Levels of Benzene
Drugs.com
MARCH 13, 2025
THURSDAY, March 13, 2025 -- After new U.S. Food and Drug Administration testing of acne products containing benzoyl peroxide, the agency determined that a small number of products should be recalled for possible benzene contamination, the FDA.
Innovations in Analytical Testing, Biopharma, and Manufacturing
Fierce BioTech
MARCH 14, 2025
Innovations in Analytical Testing, Biopharma, and Manufacturing Access our report today for a deep dive into the critical advancements shaping the future of pharmaceutical development. Discover how to ensure drugs meet the highest standards before they reach the market. smarcus Fri, 03/14/2025 - 09:39 Access our report today for a deep dive into the critical advancements shaping the future of pharmaceutical development.
FDA sets flu shot recommendations without input of outside advisers
BioPharma Drive: Drug Pricing
MARCH 14, 2025
The agency formulated its advice to manufacturers after coordinating with the CDC and Defense Department. An advisory meeting that's typically held was canceled last month.
US bird populations continue alarming decline
Science Daily: Pharmacology News
MARCH 13, 2025
The 2025 U. S. State of the Birds Report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with 229 species requiring urgent conservation action.
Joe Tufo’s Passion for Knowledge Sharing Empowers Colleague Growth
Perficient: Drug Development
MARCH 11, 2025
Perficient’s talented colleagues from around the world bring unique perspectives that spark innovation and shatter boundaries. By fostering a culture that champions growth and celebrates every individual, were forging deep, meaningful connections that drive our success. Meet Joe Tufo, lead technical consultant, whose unwavering dedication to mentoring has promoted greater collaboration across Perficients Sitecore practice.
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