Drug Target Review

SEPTEMBER 26, 2023

Early detection of neurotoxicity induced by potential new therapies is a major challenge, and hiPSC-neuronal cells may provide a solution. 2001 Sep;24(9):517–26. Human derived induced pluripotent stem cells (hiPSCs) have revolutionised research and are increasingly used for toxicology screening and disease modelling. Rudy B, McBain CJ.

Drugs 111

Drugs FDA Disease Animal Testing 111

Drug Target Review

SEPTEMBER 10, 2024

FDA no longer has to require animal testing for new drugs. Alejandro has over 15 years of experience in Biopharma working in R&D and commercial areas, where he has supported the development of a wide range of products (eg, complex recombinant proteins, AAV and cell-based therapies) and led efforts for smart biomanufacturing.

Drug Development 64

Drug Development Clinical Supply Production FDA 64

Codon

JULY 21, 2024

It may seem that if researchers are sufficiently concerned about the welfare of lab animals, the best thing to do would be to stop using animals altogether. However, a multitude of factors—from institutional inertia to a global animal-testing industry worth billions of dollars —make this outcome unlikely.

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Research Engineering Disease Science 124

Codon

NOVEMBER 1, 2024

Though my focus in this essay is narrow — I don’t discuss bottlenecks in clinical trials, human disease, or animal testing — I hope others will take on these challenges in similar essays. Today, a single injection of an FDA-approved gene therapy, called Hemgenix , cures this disease. Subscribe to Asimov Press.

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DNA RNA Molecular Biology Laboratories 122