Drug Target Review

SEPTEMBER 26, 2023

Human derived induced pluripotent stem cells (hiPSCs) have revolutionised research and are increasingly used for toxicology screening and disease modelling. 2001 Sep;24(9):517–26. Using stem cell-derived neurons in drug screening for neurological diseases. The electrophysiological development of cardiomyocytes. Trends Neurosci.

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The Pharma Data

SEPTEMBER 8, 2021

TIB Molbiol excels in ultra-rapid assay development for emerging infectious disease, strongly demonstrated during the COVID-19 pandemic. For example, in 2001 with anthrax and 2003 with SARS-CoV1, TIB Molbiol demonstrated their ability to develop PCR assays for the detection of new pathogens within days.

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The Pharma Data

JANUARY 20, 2021

More than 205,000 kids and teens have the disease, and cases are rising. children and teens with type 2 diabetes increased by 30% between 2001 and 2009, with cases growing among youth aged 10 and older. WEDNESDAY, Jan. 20, 2021 — Kids with diabetes can lead full, fun lives, but they have special needs. The number of U.S.

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PPD

MAY 11, 2023

Children and the elderly are among the most vulnerable populations and must be given special consideration in vaccine clinical trials to ensure their protection against vaccine-treatable diseases. The Many Considerations of Pediatric Vaccine Clinical Trials Childhood vaccines are highly effective in the prevention of many diseases.

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The Pharma Data

JANUARY 10, 2021

Comparing to Non-Small Cell Lung Cancer(NSCLC), it is still not clear about tumor driving gene in the development of SCLC, and thus it is lacking of targeted therapeutic treatment for this life threaten disease. SH ) was founded in Shenzhen on 2001, specializing in the research and development of novel small molecule drugs.

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Drug Target Review

FEBRUARY 28, 2024

Human γδ TCR repertoires in health and disease. Increased frequency of TCR gamma delta + T cells in disease-free survivors following T cell-depleted, partially mismatched, related donor bone marrow transplantation for leukemia. Science 294(5542):605-609 (2001). References Fichtner A, Ravens S, Prinz I. Cells 9(40):800 (2020).

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Drug Target Review

JANUARY 31, 2024

Early in my education, I developed an interest in understanding how chemical entities derived from natural resources could be modified and used to fight specific diseases. One of the biggest obstacles I faced early in my career was the perception that women often quit their career to achieve a work-life balance.

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NIH Director's Blog: Drug Development

OCTOBER 11, 2022

The first such call came in 2001, when Sharpless got the news that he was a co-winner of the Nobel Prize in Chemistry for his discovery of asymmetric catalytic reactions. 2001, 40 (11), 2004–2021 [2] A stepwise huisgen cycloaddition process: Copper(I)-catalyzed regioselective “Llgation” of azides and terminal alkynes.

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Advarra

JUNE 30, 2023

Background In 2001, Medicare released the national coverage determination (NCD) 310.1. The study must be performed to prevent, detect, or treat any serious or life-threatening disease or condition. However, a year has passed with no further updates on this letter or Medicaid beneficiaries enrolling in clinical trials.

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FDA Law Blog: Drug Discovery

APRIL 23, 2023

The Draft Guidance states that an external control group is potentially appropriate in a setting where the natural history is well-defined and the disease is known not to improve in the absence of an intervention or with available therapies. “For This is potentially discouraging to sponsors of drugs intended for rare and serious diseases.

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The Pharma Data

DECEMBER 15, 2020

Dr. Lu Xianping, Chairman of CHIPCREEN BIOSCIENCES, said: “Diabetes is one of the chronic diseases with highest incidence in the world. SH) was founded in Shenzhen on 2001, specializing in the research and development of novel small molecule drugs. China has the largest number of diabetic patients in the world.

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Conversations in Drug Development Trends

MAY 23, 2024

Regulatory Harmonization of Clinical Trials in the EU The EU-CTR repealed the Clinical Trial Directive 2001/20/EC (CTD) and national implementing legislation in the EU Member States on 31 January 2022. This blog delves into the key aspects of the EU regulatory space and provides insights into navigating these changes effectively.

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Agency IQ

APRIL 12, 2024

Directive 2001/83/EC and Regulation (EC) No 726/2004. EURORDIS , a non-profit alliance of rare disease organizations, noted the amendments as a significant step towards “bridging the gap between rapid scientific progress and the slower advancement in patient care,” highlighting that 94% of rare diseases still lack treatment.

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The Pharma Data

DECEMBER 20, 2020

Cefepime/enmetazobactam has been granted Qualified Infectious Disease Product and Fast Track designation by the U.S. Shanghai Haini) was founded in 2001. Based on these results, Allecra plans to submit, during the second half of 2021, this ß-lactam/ß-lactamase inhibitor combination for marketing approval in the U.S.

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Agency IQ

JUNE 7, 2024

Forty-eight Notified Bodies received designation for six codes, including software (MDA 0315), systems/procedure packs (MDS 1011), devices manufactured with metal (MDT 2001) or plastic processing (MDT 2002), devices with electronic components (MDT 2010) and devices requiring installation or refurbishing (MDT 2012).

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Agency IQ

MARCH 7, 2024

MHRA launched the pilot in late 2023 and ultimately chose eight products with different technologies that address life-threatening diseases with no equivalent solutions that also support the U.K.’s s Life Sciences Vision. Ultimately, the pilot will provide a standardized process to support innovative devices and their manufacturers.

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The Pharma Data

OCTOBER 19, 2020

Transthyretin Amyloidosis (ATTR) is a rare, progressive and fatal disease. Intellia has received approval to launch their Phase I trial of NTLA-2001 in hereditary ATTR. Their NTLA-2001 candidate uses their proprietary non-viral lipid nanoparticle platform, which will deliver this CRISPR/Cas9-based therapy.

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PLOS: DNA Science

AUGUST 17, 2023

That’s why fatigue is a major symptom of mitochondrial diseases – there’s a different such condition for each of the genes. Media reports often lump them together as “mitochondrial disease,” which is disturbingly non-specific for this geneticist.)

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PLOS: DNA Science

MARCH 21, 2024

Lenmeldy adds functional genes that encode the enzyme arylsulfatase A (ARSA) to bone marrow stem cells taken from children who have inherited the disease, but haven’t yet developed symptoms, which typically begin around age 2 or 3. Each of their children would face a 1 in 4 chance of inheriting the disease.

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National Institute on Drug Abuse: Nora's Blog

AUGUST 28, 2024

Excess mortality from causes including heart disease, cancer, assault, cerebrovascular disease, and diabetes is also higher among Black men. Discrimination takes a toll on mental health.

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Common Sense for Drug Policy Blog

JULY 8, 2023

Additionally, the framing of Portuguese drug addiction as a ‘disease’ is somehow pathologizing and might undermine the right to agency and self-determination of people using drugs, who still experience stigma, discrimination and sometimes violence from police, service and health-care providers and the community at large [ 7 ].

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The Pharma Data

OCTOBER 21, 2020

The disease is a subtype of ALL in which the cancer cells have a genetic abnormality called the Philadelphia chromosome (Ph). Those drugs belong to a class called tyrosine kinase inhibitors (TKIs), and include Gleevec — the first TKI approved, back in 2001 — as well as newer ones like Sprycel and Bosulif. © 2020 HealthDay.

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The Pharma Data

OCTOBER 21, 2020

The disease is a subtype of ALL in which the cancer cells have a genetic abnormality called the Philadelphia chromosome (Ph). Those drugs belong to a class called tyrosine kinase inhibitors (TKIs), and include Gleevec — the first TKI approved, back in 2001 — as well as newer ones like Sprycel and Bosulif. © 2020 HealthDay.

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PLOS: DNA Science

APRIL 13, 2023

The first SNP map was published in 2001 and the first GWAS in 2005. The new study also reveals genetic patterns that predict addiction to two or more substances, as well as elevated risk of mental and physical illnesses, including psychiatric disorders, suicidal behavior, respiratory disease, heart disease, and chronic pain conditions.

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PLOS: DNA Science

JUNE 22, 2023

Cancer cells make too much survivin, with levels increasing as the disease spreads and becomes more aggressive. It delayed disease progression and more than doubled survival time, adding 17 months. After passing safety tests, Gleevec worked so well that it set a new record for drug approval—10 weeks, on May 10, 2001.

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PLOS: DNA Science

SEPTEMBER 5, 2024

The most groundbreaking cancer drug approval was for Gleevec , with a mere 3-month trajectory at FDA before its approval in 2001. The FDA approved Herceptin , targeting a different receptor (HER2) in breast cancer cells, in 1998. Cancer clearly entails more than just errant genes.

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Broad Institute

JULY 28, 2023

Through his comprehensive investigations, he strives to advance knowledge and identify potential therapeutic interventions for stress-related psychiatric disorders and neurodegenerative diseases. The Sabatini Lab focuses on the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.

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Agency IQ

DECEMBER 15, 2023

Currently, only Article 23a and Article 81 of Directive 2001/83/EC address medicines supply across the E.U. Additionally, medicines that treat a potentially fatal condition, require immediate administration, for which an interruption of treatment would jeopardize outcomes, or are part of a national disease control program (e.g.,

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National Institute on Drug Abuse: Nora's Blog

NOVEMBER 25, 2024

2 Drug use contributes to the spread of HIV and other infectious diseases like hepatitis B and C in multiple ways, including the sharing of drug injection equipment. 2001 Nov 1;28(3):282-8. Another study in Baltimore found an especially strong effect of SSP usage on later drug treatment among people living with HIV. PMID: 11694838.

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The Pharma Data

JANUARY 13, 2021

Tonix is a clinical-stage biopharmaceutical company focused on discovering, licensing, acquiring and developing small molecules and biologics to treat and prevent human disease and alleviate suffering. 175:1091-1101 (1992) 2 Karpusas, M et al., International Immunol. (11):1583 11):1583 (2004) 6 Karpusas M, et al. Structure.

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Agency IQ

APRIL 8, 2024

The FDA created a parallel tool, called the eSubmitter which worked like the SRP with the caveat that case information was not uploaded to FAERS but to the Vaccine Adverse Event Reporting System (VAERS), a program co-monitored by both the FDA and the Centers for Disease Control and Prevention (CDC). database-to-database submissions).

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Codon

JULY 21, 2024

Of course, AA and P-line rats are not the only research animals bred for the study of disease. By doing so, researchers study pain, genetic disorders, the effect of drugs, and disease pathways in mammals that, while genetically similar to us, are not human beings. They are bred, incised, injected, and deprived.

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Codon

AUGUST 27, 2024

Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Sometimes, though, novel diseases do emerge, and as COVID-19 demonstrated, they can surprise us. This is the third essay of four in our pandemic mini-issue.

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PLOS: DNA Science

JULY 27, 2023

That information led, thanks to vaccine shelved from the first SARS circa 2003, to the rapid development and deployment of mRNA vaccines against the new infectious disease. which spit out information guiding the trimming of tumors in real time, a bit reminiscent of its ancestor Hal the computer from 2001: A Space Odyssey.

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National Drug & Alcohol Research Centre Blog

DECEMBER 17, 2020

The study cohort includes all people administered OAT in NSW between 2001 and 2018. At least 2/3 of this cohort had experienced a hospitalisation with the ICD-10 diagnosis code associated with mental and behavioural disorders due to opioids; the next most common diagnoses were injury and liver disease. Drug Alcohol Depend (in press).

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Codon

DECEMBER 12, 2024

Clarke — the British writer most famous for 2001: A Space Odyssey — published a little-known story called Technical Error , in which a power plant employee is transformed into his mirror image after an accidental short-circuit. In 2001, in an outbreak that had nothing to do with a lab leak, foot-and-mouth disease in the U.K.

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The Pharma Data

MAY 13, 2021

Non-alcoholic fatty liver disease and fructose: bad for us, better for mice. Grading scale of visceral adipose tissue thickness and their relation to the nonalcoholic fatty liver disease. Exposure to non-nutritive sweeteners during pregnancy and lactation: Impact in programming of metabolic diseases in the progeny later in life.

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