Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

DNA 102

DNA RNA Vaccine Virus 102

The Pharma Data

OCTOBER 19, 2020

Intellia has received approval to launch their Phase I trial of NTLA-2001 in hereditary ATTR. Their NTLA-2001 candidate uses their proprietary non-viral lipid nanoparticle platform, which will deliver this CRISPR/Cas9-based therapy. hATTR is an inherited DNA mutation of the TTR gene.

Therapies 52

Therapies Pharmacokinetics Trials Clinical Trials 52

Codon

FEBRUARY 20, 2024

Thanks to decades of progress in molecular sequencing technologies, it is simple to read out the order of nucleotides in a DNA sequence, for example, or to quantify messenger RNAs as they are made by a cell. The ATP synthase “bead” experiment was part of a 2001 study published in the journal Nature.

RNA 98

RNA DNA Engineering Cell Biology 98

PLOS: DNA Science

APRIL 13, 2023

“RFLPs” are sites in a DNA sequence where a bacterial enzyme, called a restriction enzyme, cuts. See The Age of the Pangenome Dawns , here at DNA Science from a few months ago.) As the first genomes were being sequenced, researchers began identifying the sites where the 4 DNA bases vary among individuals.

DNA 52

DNA Drugs Treatment Science 52

PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. After passing safety tests, Gleevec worked so well that it set a new record for drug approval—10 weeks, on May 10, 2001. The post How Targeted Cancer Drugs Disrupt the Cell Cycle appeared first on DNA Science.

Drugs 52

Drugs Small Molecule DNA Bioethics 52

Codon

JULY 21, 2024

And whereas it used to be costly for breeders to select for traits beyond the needs of their industry, the falling costs of advanced genomic selection techniques—breeding using DNA sequence data—make it increasingly fast and feasible. By contrast, knocking out FAAH makes the animals retain enough pain-signaling to avoid damage.

Research 119

Research Engineering Disease Science 119

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development.

Drug Development 64

Drug Development Clinical Supply Production FDA 64

Codon

JANUARY 2, 2024

“Hazards of Mouth Pipetting” The micropipette, an instrument favored by researchers around the world to measure and move liquids from one container to another and used for everything from forensic analysis to DNA sequencing, was invented by an obscure, 32-year-old German postdoc after a particularly productive two-day tantrum.

Laboratories 120

Laboratories DNA Licensing Licensing 120

Agency IQ

MARCH 29, 2024

April 2024 Restoration of Inadvertently-Removed Exemption from the Requirements of FIFRA (Proposed Rule Stage) 2070-AK25 In 2001, EPA inadvertently removed an exemption from the requirements of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).

Regulations 40

Regulations Compliance Production Government 40

PLOS: DNA Science

FEBRUARY 3, 2025

The correct diagnosis finally came in 2001: dilated cardiomyopathy, DCM. Dr. McNally checked Diane’s DNA for new mutations as they were discovered. The Liebman’s mutation changes a single DNA base that borders an intron and prevents the intron from being cut out properly. Diane was, and had been, in heart failure.

Disease 84

Disease DNA Doctors Science 84

Codon

JANUARY 12, 2025

He also posited the existence of a physical material to explain inheritance, which he called “elementen,” or “elements,” many years before nucleic acid had even been isolated 4 and more than 80 years before British biologists unveiled DNA’s structure and founded the field of molecular biology.

DNA 105

DNA Nurses Research Molecular Biology 105

Codon

NOVEMBER 1, 2024

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades. If we could get E.

DNA 118

DNA RNA Molecular Biology Laboratories 118

Codon

NOVEMBER 24, 2024

Because the FDA has asserted since 2001 that modification of human embryos would require its permission, this effectively bans even the testing of such technology in the U.S. while it proceeds elsewhere. Jiankui, a Chinese scientist who had done his doctoral and post-doctoral training in U.S. 10 This is not possible with current technology.

Regulations 60

Regulations DNA Hospitals Trials 60