PLOS: DNA Science

SEPTEMBER 5, 2024

The most groundbreaking cancer drug approval was for Gleevec , with a mere 3-month trajectory at FDA before its approval in 2001. The tool detects cancer cells and pinpoints the origin of the tumor, as well as identifying and assessing gene and DNA patterns to predict patient outcomes and treatment responses.

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Treatment FDA Approval DNA Small Molecule 68

PLOS: DNA Science

APRIL 13, 2023

“RFLPs” are sites in a DNA sequence where a bacterial enzyme, called a restriction enzyme, cuts. See The Age of the Pangenome Dawns , here at DNA Science from a few months ago.) As the first genomes were being sequenced, researchers began identifying the sites where the 4 DNA bases vary among individuals.

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DNA Drugs Treatment Science 52

PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. After passing safety tests, Gleevec worked so well that it set a new record for drug approval—10 weeks, on May 10, 2001. The post How Targeted Cancer Drugs Disrupt the Cell Cycle appeared first on DNA Science.

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Drugs Small Molecule DNA Clinical Trials 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Codon

JULY 21, 2024

And whereas it used to be costly for breeders to select for traits beyond the needs of their industry, the falling costs of advanced genomic selection techniques—breeding using DNA sequence data—make it increasingly fast and feasible. By contrast, knocking out FAAH makes the animals retain enough pain-signaling to avoid damage.

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Research Engineering Disease Science 120

Codon

JANUARY 2, 2024

“Hazards of Mouth Pipetting” The micropipette, an instrument favored by researchers around the world to measure and move liquids from one container to another and used for everything from forensic analysis to DNA sequencing, was invented by an obscure, 32-year-old German postdoc after a particularly productive two-day tantrum.

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Laboratories DNA Licensing Licensing 122

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

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Disease DNA Virus RNA 92

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

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RNA DNA Vaccine Virus 102

Agency IQ

MARCH 29, 2024

April 2024 Restoration of Inadvertently-Removed Exemption from the Requirements of FIFRA (Proposed Rule Stage) 2070-AK25 In 2001, EPA inadvertently removed an exemption from the requirements of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA).

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PLOS: DNA Science

FEBRUARY 3, 2025

The correct diagnosis finally came in 2001: dilated cardiomyopathy, DCM. Dr. McNally checked Diane’s DNA for new mutations as they were discovered. The Liebman’s mutation changes a single DNA base that borders an intron and prevents the intron from being cut out properly. Diane was, and had been, in heart failure.

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Disease DNA Doctors Science 80

Codon

NOVEMBER 1, 2024

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades. If we could get E.

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DNA RNA Molecular Biology Laboratories 120

Codon

JANUARY 12, 2025

He also posited the existence of a physical material to explain inheritance, which he called “elementen,” or “elements,” many years before nucleic acid had even been isolated 4 and more than 80 years before British biologists unveiled DNA’s structure and founded the field of molecular biology.

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DNA Nurses Research Molecular Biology 107

Codon

NOVEMBER 24, 2024

Because the FDA has asserted since 2001 that modification of human embryos would require its permission, this effectively bans even the testing of such technology in the U.S. while it proceeds elsewhere. Jiankui, a Chinese scientist who had done his doctoral and post-doctoral training in U.S. 10 This is not possible with current technology.

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