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Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease

PLOS: DNA Science

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease 98
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Fast Biology

Codon

Thanks to decades of progress in molecular sequencing technologies, it is simple to read out the order of nucleotides in a DNA sequence, for example, or to quantify messenger RNAs as they are made by a cell. The ATP synthase “bead” experiment was part of a 2001 study published in the journal Nature.

RNA 98
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The Dangers of Mirrored Life

Codon

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

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Defense-Forward Biosecurity

Codon

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 83
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Levers for Biological Progress

Codon

Scientists are already building a model that can, for example, look at which RNA molecules are expressed in a cell at t=0 and predict how those molecules will change at t=1. Synthesizing a single human protein-coding gene costs several hundred dollars and even a simple PCR machine (used for amplifying DNA) costs between $1,500 and $50,000.

DNA 107