PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

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Disease DNA Virus RNA 98

PLOS: DNA Science

MARCH 21, 2024

million price tag for the one-time infusion, and for the older siblings who contributed to developing the gene treatment, but were too sick to receive it. The history of gene therapy for MLD is compelling – DNA Science covered it for Rare Disease Day in 2021, here. million, a lot less than the MLD treatment.

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LifeSciVC

AUGUST 5, 2024

In 2001, I was at Millennium Pharmaceuticals, one of the major players in the nascent field of genomics drug discovery, and that time has strong parallels to the changing state of drug development today. In fact, the Millennium of 2001 (pre-Takeda acquisition) had one drug approved which was Velcade (bortezomib).

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Molecular Biology Production Small Molecule Drug Development 85

PLOS: DNA Science

SEPTEMBER 5, 2024

The most groundbreaking cancer drug approval was for Gleevec , with a mere 3-month trajectory at FDA before its approval in 2001. Diagnosis began to shift from a body-part basis to a molecular one, which I wrote about in “Mutation and location important in cancer treatment” for The Lancet in 2015.

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Treatment FDA Approval DNA Small Molecule 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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DNA Laboratories Hospitals Virus 83

The Pharma Data

OCTOBER 19, 2020

Previous treatments could only hope to slow progression. Intellia has received approval to launch their Phase I trial of NTLA-2001 in hereditary ATTR. Their NTLA-2001 candidate uses their proprietary non-viral lipid nanoparticle platform, which will deliver this CRISPR/Cas9-based therapy.

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Therapies Pharmacokinetics Trials Clinical Trials 52

PLOS: DNA Science

APRIL 13, 2023

received treatment, according to the National Institute on Drug Abuse (NIDA). So scrutinizing genomes for genes that control drug dependency could inspire treatments. “RFLPs” are sites in a DNA sequence where a bacterial enzyme, called a restriction enzyme, cuts. Drug addiction is prevalent and deadly.

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DNA Drugs Treatment Science 52