Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s. References: Békés M, Langley DR, Crews CM.

Targeted Protein Degradation 98

Targeted Protein Degradation Small Molecule Clinical Trials Science 98

The Pharma Data

DECEMBER 15, 2020

Such cooperation will rapidly expand the coverage of the drug product after its launch, providing professional pharmaceutical services to doctors and patients, and benefit more patients.” SH) was founded in Shenzhen on 2001, specializing in the research and development of novel small molecule drugs.

Pharmaceuticals 40

Pharmaceuticals Clinical Trials Small Molecule Disease 40

Codon

AUGUST 27, 2024

Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. Nevertheless, the costs of DNA sequencing have dropped since 2001 , and since 2008 have decreased at a pace more rapid than that which Moore’s Law predicts for computing power.

DNA 102

DNA Laboratories Hospitals Virus 102

Codon

DECEMBER 12, 2024

7 During the few years that thalidomide was available on the market — and before Australian doctor William McBride warned of its consequences in a letter published in The Lancet in 1961 — it affected more than 10,000 babies, killing about half of them within months after birth. The report maps out at least three options.

DNA 104

DNA RNA Vaccine Virus 104