Drug Target Review

JULY 6, 2023

1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. 1 The concept of TPD was first demonstrated with a heterobifunctional small molecule to degrader a protein of interest in the early 2000s. USA 98, 8554-8559 (2001) Zhang G, Zhang J, Gao Y, et al.

Targeted Protein Degradation 98

Targeted Protein Degradation Small Molecule Clinical Trials Science 98

Drug Target Review

APRIL 7, 2025

Novel mechanisms of action associated with CGTs naturally create dosing effects that apply in very different ways than with traditional small molecule pharmacotherapies. 2001) Biomarkers Definitions Working Group Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Bagyinszky E, et al. 21(10):3517.

Clinical Development 59

Clinical Development Clinical Trials Clinical Pharmacology Trials 59

LifeSciVC

AUGUST 5, 2024

In 2001, I was at Millennium Pharmaceuticals, one of the major players in the nascent field of genomics drug discovery, and that time has strong parallels to the changing state of drug development today. In fact, the Millennium of 2001 (pre-Takeda acquisition) had one drug approved which was Velcade (bortezomib).

Molecular Biology 90

Molecular Biology Production Drug Development Small Molecule 90

Drug Target Review

NOVEMBER 1, 2023

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. We have several exciting projects in various stages of discovery, but a small-molecule drug that is causing a lot of excitement at the moment is Capivasertib.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

NIH Director's Blog: Drug Development

OCTOBER 11, 2022

The first such call came in 2001, when Sharpless got the news that he was a co-winner of the Nobel Prize in Chemistry for his discovery of asymmetric catalytic reactions. For clinical researchers, click chemistry has emerged as a workhorse in drug discovery and the improved targeting of cancer chemotherapies and other small-molecule drugs.

Research 52

Research Small Molecule Science Clinical Research 52

The Pharma Data

JANUARY 10, 2021

SH ) was founded in Shenzhen on 2001, specializing in the research and development of novel small molecule drugs. About CHIPSCREEN BIOSCIENCES. Shenzhen Chipscreen Biosciences Co., Chipscreen Biosciences, Stock Symbol: 688321.

Clinical Trials 52

Clinical Trials Treatment Trials Small Molecule 52

The Pharma Data

DECEMBER 15, 2020

SH) was founded in Shenzhen on 2001, specializing in the research and development of novel small molecule drugs. .” About CHIPSCREEN BIOSCIENCES. Shenzhen Chipscreen Biosciences Co., Chipscreen Biosciences, Stock Symbol: 688321.SH)

Pharmaceuticals 40

Pharmaceuticals Clinical Trials Small Molecule Disease 40