Alta Sciences

SEPTEMBER 13, 2023

Four Pain Models Altasciences Uses to Assess Treatments During Clinical Trials pmjackson Wed, 09/13/2023 - 17:01 September is pain awareness month, and the importance of pain management and continued research into effective analgesics is integral to helping patients suffering from various pain conditions. Tags Clinical Trials Weight 1

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Drug Discovery World

JULY 25, 2023

Triebel founded Immutep SA in 2001 to develop the clinical potential of LAG-3 and stayed with this company through to its acquisition by Prima BioMed in 2014. DDW Volume 24 – Issue 2, Spring 2023 – Global Cancer Research Guide Biography: Frédéric Triebel, MD PhD, founded Immutep in 2001.

Immune Response 246

Immune Response Therapies Vaccine Production 246

Drug Discovery World

NOVEMBER 24, 2022

Despite the importance of the pharmaceutical industry to national economies and population health, the report paints a picture of falling competitiveness, with the global share of R&D investment, clinical trials and manufacturing output all decreasing. . Overall clinical trial activity in the region is also on the decline.

Therapies 245

Therapies Clinical Trials Pharmaceuticals Government 245

PLOS: DNA Science

MARCH 21, 2024

A Long and Winding Diagnostic Road The story begins in 2011, with Alessandra Biffi, MD, head of the clinical trial for MLD at the San Raffaele Telethon Institute for Gene Therapy in Milan. Two of their children, Liviana and Giovanni, participated in the clinical trial. She passed away in 2013. Yes, the cost is horrifying.

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Therapies Clinical Trials DNA Trials 78

Drug Discovery World

NOVEMBER 29, 2022

This ranges from understanding disease processes and identifying possible drug targets, to organising testing, rolling out clinical trials, negotiating complex regulations and licensing and finally, treating patients. Drug development and clinical trials: How drugs are discovered and developed as medicines. Providing a broad view.

Clinical Pharmacology 130

Clinical Pharmacology Clinical Trials Drugs Drug Development 130

PPD

MAY 11, 2023

To effectively implement vaccine clinical trials for special populations, it is critical for vaccine developers to partner with a contract research organization (CRO) that has demonstrated experience recruiting and retaining pediatric and elderly study participants — and managing the nuances these patients and their caregivers require.

Vaccine 52

Vaccine Clinical Trials Long-Term Care Facilities Trials 52

Drug Discovery World

JULY 3, 2024

The data from the ongoing Phase I study of NTLA-2001, a single-dose treatment in development for transthyretin (ATTR) amyloidosis, were presented at the Peripheral Nerve Society Annual Meeting. Development and commercialisation of NTLA-2001 is led by Intellia as part of a multi-target collaboration with Regeneron.

Therapies 147

Therapies Trials Treatment Disease 147

The Pharma Data

JANUARY 27, 2021

years) participating in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (1993 to 2001). Loomans-Kropp, Ph.D., The analysis included 139,896 individuals (mean age, 66.4 The researchers found that aspirin use was not associated with the incidence of any studied cancer type.

Trials 52

Trials Research 52

Drug Target Review

JULY 6, 2023

Programme : the leader programme ASP3082 entered the clinical trial phase last year, and multiple forum programmes are currently under investigation in the light research phase. USA 98, 8554-8559 (2001) Zhang G, Zhang J, Gao Y, et al. ASP3082 experienced an expedited R&D process as it was targeting the KRAS G12D mutation.

Targeted Protein Degradation 98

Targeted Protein Degradation Small Molecule Clinical Trials Science 98

DrugBaron

JANUARY 8, 2021

But before doing so, its worth reading a few paragraphs from a Commentary on gene therapy that DrugBaron wrote in 2001, marking the first publication of the completed human genome sequence, just to remind us that the central flaw in the Sarepta story was well-known two decades ago.

DNA 100

DNA Therapies Disease Production 100

Drug Target Review

JANUARY 31, 2024

Since joining Allergan Aesthetics in 2001, my role in medical affairs has always focused, in one way or another, on supporting the journey of a drug/device from bench to bedside. One of the biggest obstacles I faced early in my career was the perception that women often quit their career to achieve a work-life balance.

Clinical Trials 97

Clinical Trials Production Science Research 97

PLOS: DNA Science

JUNE 22, 2023

I recalled Heather’s early mastery of mitosis last week when the news reported promising clinical trial results for a cancer drug for brain tumors that targets a protein, called survivin , that controls the cell cycle. ” “Doesn’t everyone?” ” she answered. It must have been challenging being my kid.

Drugs 52

Drugs Small Molecule DNA Bioethics 52

Drug Target Review

NOVEMBER 1, 2023

The mission of the CCDD is to discover novel small-molecule therapeutics for the treatment of cancer and progress them to hypothesis testing phase 1 clinical trials. In 2001, he joined Astex Pharmaceuticals in Cambridge where he became an expert in fragment-based drug discovery working on diabetes, thrombotic and oncology drug targets.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Drug Discovery World

OCTOBER 16, 2023

CellProthera selected the UK centres for their excellence in the conduct of clinical research with dedicated staff, equipment, availability of imaging platforms and high interest in cell therapy cardiovascular trials especially University Hospital of Birmingham equipped with a bi-plane Cathlab.

Drugs 189

Drugs Science Therapies Targeted Protein Degradation 189

The Pharma Data

OCTOBER 21, 2020

In a trial of 63 patients, researchers found that the drug regimen frequently wiped out all signs of the cancer — a subtype of the blood cancer acute lymphoblastic leukemia (ALL). Park, a leukemia specialist at Memorial Sloan Kettering Cancer Center in New York City, was not involved in the trial. WEDNESDAY, Oct.

Therapies 52

Therapies Drugs Treatment Trials 52

The Pharma Data

OCTOBER 21, 2020

In a trial of 63 patients, researchers found that the drug regimen frequently wiped out all signs of the cancer — a subtype of the blood cancer acute lymphoblastic leukemia (ALL). Park, a leukemia specialist at Memorial Sloan Kettering Cancer Center in New York City, was not involved in the trial. WEDNESDAY, Oct.

Therapies 52

Therapies Drugs Treatment Trials 52

Conversations in Drug Development Trends

MAY 23, 2024

By: Sarah Bly, Regulatory Science and Innovation and Matt Cooper, Executive Director, Therapeutic Strategy Lead, Oncology The European Union (EU) presents a unique set of regulatory challenges and opportunities for clinical trials in oncology. Increased Transparency : Ensures that information on clinical trials is more accessible.

Trials 52

Trials Clinical Trials Therapies Regulations 52

PLOS: DNA Science

JULY 27, 2023

which spit out information guiding the trimming of tumors in real time, a bit reminiscent of its ancestor Hal the computer from 2001: A Space Odyssey. Next up: testing in real-world settings and submission of clinical trial findings to the FDA. And then in 2001 came us. Duke University neurosurgeon Oren Gottfried voiced 2.0,

Disease 69

Disease DNA Virus RNA 69

The Pharma Data

DECEMBER 15, 2020

As the world’s first PPAR pan agonist that completed two confirmatory phase III clinical trials, Chiglitazar Sodium has shown significant and long-lasting hypoglycemic effects in a series of clinical studies, as well as other comprehensive effects including significant insulin sensitization and blood lipid regulation.

Pharmaceuticals 40

Pharmaceuticals Small Molecule Clinical Trials Production 40

FDA Law Blog: Drug Discovery

APRIL 23, 2023

This Draft Guidance focuses on the use of patient-level data from other clinical trials or from RWD sources. For example, objective response rate is often used as a single-arm trial endpoint in oncology given the established understanding that tumor shrinkage rarely occurs without an intervention.”

Trials 49

Trials Clinical Trials FDA Treatment 49

The Pharma Data

DECEMBER 20, 2020

Cefepime/enmetazobactam has shown superiority over standard of care in patients with complicated urinary tract infections (cUTIs) in a randomized, controlled, double-blind, global Phase 3 trial. Shanghai Haini) was founded in 2001. and EU based on these results. For more information, please visit our website, www.yangzijiang.com.

Licensing 40

Licensing Licensing Pharmaceuticals Pharmaceutical Companies 40

The Pharma Data

JANUARY 13, 2021

we determined the crystal structure of CD40-ligand 2 , developed a humanized version of our antibody (hu5c8, ruplizumab, or Antova®) and tested it in human trials for preventing organ transplant rejection and autoimmunity. Collaborating with a team at Biogen Inc., 175:1091-1101 (1992) 2 Karpusas, M et al., International Immunol. (11):1583

Pharmaceuticals 52

Pharmaceuticals Small Molecule Vaccine Protein Expression 52

Drug Discovery World

JANUARY 23, 2023

Implementation of the EU Clinical Trials Regulation The way clinical trials (CTs) are conducted in the European Union (EU) underwent a major change when the Clinical Trial Regulation (CTR) EU No 536/2014 came into force on 31 January 2022.

Clinical Trials 130

Clinical Trials FDA Drug Development Compliance 130

Drug Discovery World

AUGUST 2, 2023

Based on this data, ezurpimtrostat completed a first-in-human clinical trial for patients with advanced cancer 5 showing sustained stabilisation in heavily pre- treated patient with mild toxicity. DDW Volume 24 – Issue 2, Spring 2023 – Global Cancer Research Guide References Busquets-Hernández C, Triola G.

Small Molecule 130

Small Molecule Immune Response Clinical Trials International 130

Practical Cheminformatics

JUNE 12, 2023

In the figure below, I performed 1000 trials, selecting a random LogS value from the BSD and adding normally distributed noise from a normal distribution centered at 0 with standard deviations of 0.17, 0.5, While previous publications estimated the experimental error in solubility measurements at 0.6 LogS = 0.5 - 0.01(MP

Drugs 130

Drugs Trials 130

Drug Discovery World

AUGUST 24, 2023

These three newly funded clinical trials represent the careful research that is urgently needed to build upon preliminary findings, and guide clinical practice in Canada 5.” In the UK, psilocybin is a Schedule I drug and therefore illegal, but there are growing calls for its reclassification to allow for therapeutic use.

Clinical Trials 130

Clinical Trials Treatment Regulations Trials 130

Drug Discovery World

MAY 12, 2023

The concept was first described by Dr Sharpless in 2001 and further refined by Dr Sharpless and Dr Meldal (working independently) in 2004 1. An ongoing Phase II clinical trial is evaluating the safety, tolerability, and ability of SQ3370 to shrink solid tumours and extend survival. 2001, 40, 2004-2021. Proc Natl Acad Sci U S A.

Organic Chemistry 130

Organic Chemistry Therapies Immune Response Treatment 130

The Pharma Data

JANUARY 10, 2021

SH ) submitted its pivotal phase III clinical trial application (IND) of national class I innovative drug Chiauranib to NMPA, for the treatment of Small Cell Lung Cancer (SCLC) as a single agent for the patients after 2nd-line systemic chemotherapy and recurrence afterwards. SHENZHEN, China , Jan. Chipscreen Biosciences, Stock Symbol: 688321.SH

Clinical Trials 52

Clinical Trials Trials Treatment Small Molecule 52

The Pharma Data

OCTOBER 19, 2020

Intellia has received approval to launch their Phase I trial of NTLA-2001 in hereditary ATTR. Their NTLA-2001 candidate uses their proprietary non-viral lipid nanoparticle platform, which will deliver this CRISPR/Cas9-based therapy. hATTR is an inherited DNA mutation of the TTR gene.

Therapies 52

Therapies Pharmacokinetics DNA Trials 52

Drug Target Review

FEBRUARY 28, 2024

Preclinical research on γδ T cells has made great strides since the cells were first identified in the 1980s, with γδ T-cell therapies from several companies, including IN8bio, now in or nearing clinical trials for various cancers. Science 294(5542):605-609 (2001). J Hemotother 5(5):503-9 (1996). Girardi M, Glusac R, Filler R, et al.

Therapies 104

Therapies Engineering Molecular Biology Immune Response 104

Drug Target Review

SEPTEMBER 26, 2023

Dr Rockley previously completed an MSc in Cancer Pharmacology and have experience in clinical research from an oncology clinical trial coordinator role. 2001 Sep;24(9):517–26. References Blinova K, Stohlman J, Vicente J, Chan D, Johannesen L, Hortigon-Vinagre MP, et al. The electrophysiological development of cardiomyocytes.

Drugs 110

Drugs FDA Disease Animal Testing 110

Agency IQ

APRIL 8, 2024

In 2012, the passage of the FDA Safety and Innovation Act (FDASIA) created a new requirement for sponsors to submit all drug submissions, including clinical trial applications, in an electronic format as specified by FDA guidance.

FDA 40

FDA Production Regulations Vaccine 40

The Pharma Data

MAY 13, 2021

Nel 2001 la mia salute stava andando. Nel corso degli anni ho usato grandi. quantità di vitamine, minerali e vari integratori per cercare di normalizzare. i livelli di grasso nel sangue. I risultati sono stati molto scarsi e nel. corso del tempo i livelli di colesterolo erano saliti fino a quasi 400. Le cose comunque. del rischio di diabete.

FDA 52

FDA Production Vaccine Trials 52

Agency IQ

JANUARY 26, 2024

Such a situation is commonplace in the clinical trial realm, in which investigational drug products which are not already FDA approved are administered to patients. In 2001, the American Medical Association (AMA) conducted a survey of relevant stakeholders – including PhRMA, the U.S.

Science 40

Science FDA Packaging Production 40

Drug Discovery World

OCTOBER 7, 2022

Recent studies have shown that academic inventors contributed 37% of cancer medicines between 2001-2019. A common obstacle for researchers wanting to translate their ideas is lack of access to funding, industry-grade resources, and expertise; without access to these, academic ideas often fall at an early hurdle. .

Pharma Companies 130

Pharma Companies Science Research Drug Development 130

Codon

MARCH 28, 2023

There was nothing left over for human trials, until an opportune call came from Elon Musk’s secretary. The money was earmarked for human trials and, afterward, to develop a neural prosthesis that could augment memories in healthy adults. ” Musk later wrote a check for one million dollars.

Engineering 52

Engineering Research Science FDA Approval 52

The Pharma Data

MAY 13, 2021

2001 Nov 16;12(16):3549-52. based weight loss intervention in adults with obesity: A randomized clinical trial. 2001 Sep;30(3):765-85. Reduced Reward-driven Eating Accounts for the Impact of a Mindfulness-Based Diet and Exercise Intervention on Weight Loss: Data from the SHINE Randomized Controlled Trial. Neuroreport.

Disease 52

Disease Production Testimonials Science 52