How Targeted Cancer Drugs Disrupt the Cell Cycle
PLOS: DNA Science
JUNE 22, 2023
The candidate drug, vorasidenib, is a small molecule that inhibits survivin. Here’s an article from 2002. Gleevec came from a massive effort throughout the 1980s to screen more than 400 small molecules for one that would block the activity of the errant tyrosine kinase, without derailing other important enzymes.
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