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Defense-Forward Biosecurity

Codon

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 87
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New insight into BRCA2 gene mutations and cancer risk

Drug Target Review

Researchers from the University of California, Davis delved deeper into the mechanisms of DNA repair and cancer development by studying the BRCA2 gene at the molecular level. The study’s findings provide new insights into the origins of cancer and DNA repair mechanisms.

DNA 52
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Determining Disease Risks Based on Genetic Ancestry Can Counter Health Care Disparities, But Doesn’t Go Far Enough

PLOS: DNA Science

Tools to Track Disease: Biobanks to AI The new investigation looks at points in a human genome that can be any of the four types of DNA building blocks – A, C, T, or G. DNA samples used in genetic research came mostly from deCODE Genetics (begun in 1996, on the Icelandic population) and the UK Biobank (begun in 2006).

Disease 52
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Experimental Myotonic Dystrophy Treatment Teams Monoclonal Antibody and siRNA

PLOS: DNA Science

In these 50 or so conditions, symptoms may appear earlier and worsen from generation to generation, as the mutant gene grows, adding copies of a 3- or 4-base DNA sequence. The duo is designed to correct the mutation, the MAb targeting the siRNA to the gene behind MD1, where it snips out DNA repeats.

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The Dangers of Mirrored Life

Codon

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

DNA 100
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Topical Gene Therapy FDA-Approved for Severe Skin Disease, Dystrophic Epidermolysis Bullosa

PLOS: DNA Science

DEB has been a candidate for a gene therapy since 2002. This DNA Science post from 2018 traces the history of the efforts. ” The post Topical Gene Therapy FDA-Approved for Severe Skin Disease, Dystrophic Epidermolysis Bullosa appeared first on DNA Science. RDEB is inherited from two carrier parents.

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Sanofi’s Board of Directors proposes the appointment of Carole Ferrand, Emile Voest and Antoine Yver as independent Directors

The Pharma Data

After ten years at Sony France as Chief Financial Officer (2000-2002), and then General Secretary, she was appointed Chief Financial Officer of Europacorp Group in 2011. She began her career in 1992 at PricewaterhouseCoopers where she worked as an auditor and then a financial advisor.