NIH Director's Blog: Drug Development

MAY 15, 2018

It relies on transposons—snippets of DNA sometimes referred to as “jumping genes” for inserting themselves randomly into the genome—to disrupt thousands of genes in the P. 2002 Oct 3;419(6906):498-511. [3] falciparum genome. 3] Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis.

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Drug Development Drugs Disease Vaccine 52

PLOS: DNA Science

SEPTEMBER 28, 2023

Tools to Track Disease: Biobanks to AI The new investigation looks at points in a human genome that can be any of the four types of DNA building blocks – A, C, T, or G. DNA samples used in genetic research came mostly from deCODE Genetics (begun in 1996, on the Icelandic population) and the UK Biobank (begun in 2006).

Disease 52

Disease DNA Science Research 52

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., 8, 3527-3538, 2002). 13, 261-91, 1997). Konig et al., Cancer Res.

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Production DNA RNA Regulations 63

PLOS: DNA Science

JULY 11, 2024

In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned from reptile DNA in mosquitoes fossilized in amber, with modern frog DNA filling in gaps. The animals were cloned from DNA in bits of preserved ear bones, and doctored a bit. percent of our DNA sequence with chimps?

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DNA Science Doctors Engineering 52

PLOS: DNA Science

MAY 25, 2023

In these 50 or so conditions, symptoms may appear earlier and worsen from generation to generation, as the mutant gene grows, adding copies of a 3- or 4-base DNA sequence. The duo is designed to correct the mutation, the MAb targeting the siRNA to the gene behind MD1, where it snips out DNA repeats.

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Treatment DNA RNA Clinical Trials 52

Drug Discovery World

JANUARY 23, 2023

Such stocks have already been created using conventional CRISPR-Cas9 approaches; however, cells edited with CRISPR-Cas9 have an increased risk of random insertions and deletions (indels) which are introduced during a cell’s intrinsic DNA repair process following a DNA double strand break (DSB) from Cas9. 1995;332(4):217–223.

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Therapies DNA Engineering RNA 130

Drug Target Review

MAY 11, 2023

Researchers from the University of California, Davis delved deeper into the mechanisms of DNA repair and cancer development by studying the BRCA2 gene at the molecular level. The study’s findings provide new insights into the origins of cancer and DNA repair mechanisms.

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DNA International Research Treatment 52

PLOS: DNA Science

JUNE 1, 2023

DEB has been a candidate for a gene therapy since 2002. This DNA Science post from 2018 traces the history of the efforts. ” The post Topical Gene Therapy FDA-Approved for Severe Skin Disease, Dystrophic Epidermolysis Bullosa appeared first on DNA Science. RDEB is inherited from two carrier parents.

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FDA Approval Therapies FDA Disease 52

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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DNA Engineering RNA Therapies 52

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death. Alberts B, 2002, Energy Conversion: Mitochondria and Chloroplasts, Molecular Biology of the Cell (4th ed.). 7 (3): 276–82. PMC 1456893.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

Engineering 87

Engineering Vaccine Production RNA 87

Agency IQ

MARCH 29, 2024

The Rubber Tire Manufacturing NESHAP, subpart XXXX, was promulgated pursuant to section 112(d) of the Clean Air Act (CAA) on July 9, 2002, with corrections promulgated on March 12, 2003. EPA, 955 F.3d 3d 1088 (D.C. 2020) (“LEAN”).

Regulations 40

Regulations Compliance Production Government 40

Codon

AUGUST 10, 2023

Cell (2002). Nature Genetics (2002). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Scitable, by Nature Education.

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DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

Cell (2002). Nature Genetics (2002). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Reinberg D. & Shamir R.

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DNA Cell Biology Engineering Molecular Biology 52