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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

Consequently, electrophysiological techniques need to be developed that can provide better translation from small mammalian hearts into larger hearts and then on into human clinical trials. Figure 3: Electrograms (left panel) are recorded at increasingly short intervals between the stimuli (the ‘S1S2 interval’). 96(5): 549-558. Tisdale et al.

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