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‘Proactive’ vaccine can protect against unknown future coronaviruses

Drug Discovery World

Researchers have developed a new vaccine technology that can provide protection against a broad range of coronaviruses with potential for future disease outbreaks – including ones we don’t know about yet. Building protective vaccines before a pandemic emerges “We don’t have to wait for new coronaviruses to emerge.

Vaccine 130
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One coronavirus vaccine may protect against other coronaviruse

The Pharma Data

Northwestern Medicine scientists have shown for the first time that coronavirus vaccines and prior coronavirus infections can provide broad immunity against other, similar coronaviruses. The findings build a rationale for universal coronavirus vaccines that could prove useful in the face of future epidemics.

Vaccine 40
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Alzheimer’s disease community from our Head of Research and Development, Alfred Sandrock, M.D., Ph.D.

The Pharma Data

NOTE: ADUHELM TM (aducanumab-avwa)injection 100 mg/mL solutionis indicated for the treatment of Alzheimer’s disease. Treatment with ADUHELM should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which treatment was initiated in clinical trials. Biogen Inc.

Disease 52
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Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease

PLOS: DNA Science

That information led, thanks to vaccine shelved from the first SARS circa 2003, to the rapid development and deployment of mRNA vaccines against the new infectious disease. I tracked the numbers of sequenced SARS-CoV-2 genomes posted at GISAID every few days during the pandemic, contributed by researchers everywhere.

Disease 69
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Enlisting Monoclonal Antibodies in the Fight Against COVID-19

NIH Director's Blog: Drug Development

Science, 2020 We now know that the immune system of nearly everyone who recovers from COVID-19 produces antibodies against SARS-CoV-2, the novel coronavirus that causes this easily transmitted respiratory disease [1]. They were then able to produce many identical copies of each antibody, referred to as monoclonal antibodies.

Virus 52
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CHMP positive opinion recommending approval of Benlysta for adult patients with active lupus nephritis

The Pharma Data

It causes inflammation in the kidneys and can lead to end-stage kidney disease which may require dialysis or a transplant. 2] LN can lead to end-stage kidney disease, which requires kidney dialysis or a transplant. Approximately 20% of patients with LN progress to end-stage kidney disease within 10 years of diagnosis. [5].

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Finding New Ways to Fight Coronavirus … From Studying Bats

NIH Director's Blog: Drug Development

He uses these fundamental insights to guide the design of vaccines and therapeutics, including promising monoclonal antibodies. More importantly for Veesler’s research, bats host a wide range of viruses—more than any other mammal species. But Veesler doesn’t consider himself a visionary by expanding his research to bats.

Virus 52