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Groundbreaking strategies like proteolysis-targeting chimeric molecules (PROTACs) are also being explored. 6 Combining the effect of payloads with different mechanisms of action – an approach that revolutionised smallmolecule chemotherapy – also holds the promise of enhanced therapeutic activity for ADCs.
One advantage of this class of therapeutics is that the timelines for their development, testing, and approval are typically shorter than those for drugs made of chemical compounds, called smallmolecules. In the U.S. Stay tuned for more information about these potentially significant advances in the next few months. medRxiv.
Extra pieces of data, including proteins, lipids, or smallmolecules, are helpful when a particular DNA sequence is difficult to amplify or isolate from a sample, or when sequencing results don’t point squarely at a single disease-causing organism.
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