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‘Proactive’ vaccine can protect against unknown future coronaviruses

Drug Discovery World

The key to the vaccine’s effectiveness is the fact that the specific virus regions that it targets also appear in many related coronaviruses . By training the immune system to attack these regions, it gives protection against other coronaviruses not represented in the vaccine.

Vaccine 130
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Finding New Ways to Fight Coronavirus … From Studying Bats

NIH Director's Blog: Drug Development

Yet they are the source for many of the viruses that have spilled over into humans with devastating effect, including rabies, Ebola virus, Nipah and Hendra viruses, severe acute respiratory syndrome coronavirus (SARS-CoV), and, likely, SARS-CoV-2. Despite carrying all of these viruses, bats rarely show symptoms of being sick.

Virus 52
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Enlisting Monoclonal Antibodies in the Fight Against COVID-19

NIH Director's Blog: Drug Development

B38 blocks SARS-CoV-2 from binding to the ACE2 receptor (light pink) of a human cell, ACE2 is what the virus uses to infect cells. References : [1] Humoral immune response and prolonged PCR positivity in a cohort of 1343 SARS-CoV 2 patients in the New York City region. In the U.S. In the U.S. medRxiv.

Virus 52