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Scientific workflow for hypothesis testing in drug discovery: Part 1

Drug Target Review

This includes verifying the experimental design and understanding how the data was generated whether it was from RNA sequencing, mass spectrometry, or other biological assays. As a business executive at IBM Research in New York, Dr Singh led the go-to-market for IBM Watson Genomics Analytics.

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Preliminary Findings from a Phase 2a Trial of Investigational COVID-19 Therapeutic Molnupiravir

The Pharma Data

Molnupiravir (EIDD-2801/MK-4482) is an investigational, orally-bioavailable form of a potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. About Ridgeback Biotherapeutics.

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Kickstarting the use of AI for biotechs: part two

Drug Target Review

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). Google DeepMind’s new AI can model DNA, RNA, and ‘all life’s molecules’. As a business executive at IBM Research in New York, Dr Singh led the go-to-market for IBM Watson Genomics Analytics. Alphafold 3.0: the AI protein predictor gets an upgrade.

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Next Generation Sequencing (NGS): why is quantifying nucleic acids important? | BMG LABTECH

BMG Labtech

In contrast, long-read sequencing analyzes longer strands of DNA or RNA in one go without breaking the long strands into smaller fragments. DNA extraction and quality control Before sequencing can start, nucleic acid samples (DNA or RNA) must be prepared for analysis which involves their extraction from a biological sample.

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Cave Coronavirus in Wuhan Lab Seeded COVID – The Truth Has Always Been Out There, in the Genetics

PLOS: DNA Science

Through graphics and five main points, Chan countered the wet market scenario of the pandemic’s beginnings. The evidence supporting viral origin at the Huanan seafood market was never compelling – it just seemed possible. Her points: 1. An altered virus could have escaped. ” So ended my 2021 blog post a month later.

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Gylden’s gold platform trains T cells to kill viruses

Drug Target Review

Now, his focus is on Gylden Pharma’s nanoparticle-based vaccine platform – a cutting-edge solution that bypasses the limitations of traditional RNA and live attenuated virus vaccines. Most vaccines struggle to keep up with rapidly mutating RNA viruses like flu, dengue, and coronaviruses.

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Levers for Biological Progress

Codon

Scientists are already building a model that can, for example, look at which RNA molecules are expressed in a cell at t=0 and predict how those molecules will change at t=1. A first draft was published in 2003; it was a patchwork of sequenced DNA from multiple people. But these models will become increasingly sophisticated over time.

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