Antibody-drug conjugates payloads: then, now and next
Drug Target Review
OCTOBER 4, 2023
HSP90 inhibitors HSP90, a major chaperone protein often overexpressed in tumours, has been targeted by inhibitors derived from the geldanamycin backbone. 7 These inhibitors have faced challenges such as dose-limiting toxicity and poor pharmacokinetics, but geldanamycin ADCs have demonstrated increased survival in mice.
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