ASPET

AUGUST 21, 2024

ICH established S7B and E14 guidelines in 2005 to prevent drug-induced torsade de pointes (TdP), effectively preventing the development of high-risk drugs. However, those guidelines unfortunately hampered the development of some potentially valuable drug candidates despite not being proven to be proarrhythmic.

Compliance 100

Compliance Pharmacokinetics Drugs Engineering 100

Drugs.com

JULY 20, 2023

First diagnosed with HIV in 1990, the man had been taking antiretroviral drugs since 2005 and. THURSDAY, July 20, 2023 -- It’s rare for someone with HIV to go into remission and be considered "cured," but a European man may be the sixth to do so.

Drugs 75

Drugs 75

Cytel

NOVEMBER 1, 2023

It feels like just yesterday I attended my first PHUSE conference back in 2005 in Heidelberg, Germany. Fast forward 19 years, and the pharmaceutical industry landscape has undergone significant transformations.

Pharmaceuticals 59

Pharmaceuticals Science 59

addgene Blog

JUNE 27, 2023

In 2005, Boyden et al. described the first light-activated tool for controlling neuronal activity, channelrhodopsin-2 (ChR2), a blue light-activated cation channel, from the archaebacteria Chlamydomonas reinhardtii.

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Common Sense for Drug Policy Blog

OCTOBER 29, 2024

An additional study of the naloxone doses used in opioid reversals reported to this Pittsburgh SSP, from August 2005 to January 2023, found that from 2010 to 2023, the average dose per reversal was below two administered doses (Bell & Dasgupta, 2024). Although the proportion of opioid overdose deaths attributed to fentanyl grew from 3.5%

Production 52

Production Drugs 52

Common Sense for Drug Policy Blog

FEBRUARY 22, 2024

"Leshner and others argued that broad societal acceptance of the BDMA would deliver more effective addiction treatments that health insurers would fund and make more accessible to persons with addictions ( Volkow and Li, 2004 , Dackis and O’Brien, 2005 , Leshner, 1997 ).

Disease 52

Disease Treatment Drugs 52

Metabolite Tales Blog

JULY 4, 2024

2005; 338(1):450-455. It is known that cytochrome P450s (CYPs) catalyse the oxidation of thiophenes with the simultaneous formation of two reactive intermediates, a thiophene-S-oxide and a thiophene epoxide (Dansette et al., References Dansette PM, Bertho G, Mansuy D. Biochem Biophys Res Commun. Drug Metabol Drug Interact.

Drugs 52

Drugs 52

Common Sense for Drug Policy Blog

JANUARY 5, 2024

Its first major use was during World War II, when soldiers used it to boost their performance and alertness, and to suppress appetite (see also Braswell 2005 ; Rawson et al. Three years after the war, in 1948, the Japanese Ministry of Health prohibited the production of both tablet and powder form of methamphetamine.

Pharmacy 52

Pharmacy Regulations Production Marketing 52

Agency IQ

AUGUST 18, 2023

The EPA initially adopted a carcinogen classification scheme in 1986 before revising it in 2005. However, not all substances classified under the 1986 framework were reclassified when the 2005 guidelines were published, meaning that both schemes still hold relevance today. by inhalation, but not ingestion).

International 40

International Regulations Packaging Animal Testing 40

FDA Law Blog: Biosimilars

SEPTEMBER 26, 2023

Since I entered the life sciences industry in 2005, I’ve respected HP&M and admired their expertise and elite standing,” said Grizzel. “I Ellison, HP&M’s Managing Director. I’m incredibly excited by the opportunity to work for HP&M and its amazing group of professionals.

Marketing 57

Marketing Compliance Science FDA 57

LifeSciVC

OCTOBER 28, 2024

In its aftermath, the nuclear winter of 2002-2005 occurred in the capital markets, and it had a profoundly “anti-platform” bias. As the cycle progressed after 2005, the market’s risk appetite returned a bit before the financial crisis, and investors started to invest more actively across the asset-and-platform spectrum again.

Licensing 92

Licensing Licensing Marketing Targeted Protein Degradation 92

FDA Law Blog: Biosimilars

AUGUST 21, 2023

Investigators also found that the pharmacy sold pseudoephedrine (“PSE”) products but failed to self-certify in violation of the Combat Methamphetamine Act of 2005 (“CMEA”). We note that in December 2020, the same U.S. 2, 2020 ( DOJ Press Release ). 21 U.S.C. § 830(e)(1)(B)(i).

Pharmacy 52

Pharmacy Regulations Production Laboratories 52

Drug Target Review

DECEMBER 29, 2023

2005 June 14 [cited 2023 October 13]; 10(3):283-290. Hoorn EJ, Gonzales PA, Gross P, Frokiaer J, Knepper MA, Pisitkun T et al. Prospects for urinary proteomics: Exosomes as a source of urinary biomarkers (Review Article). Nephrology [Internet]. Available from: [link]

Disease 126

Disease Science Hospitals Treatment 126

The Pharma Data

DECEMBER 3, 2020

Data were included for 1,018,136 live, singleton births in NHS hospitals between January 2005 and December 2006. 1, 2005, and March 31, 2015; 63 percent were emergency admissions. Victoria Coathup, Ph.D., The researchers identified 1,315,338 admissions between Jan.

Hospitals 52

Hospitals Research 52

Common Sense for Drug Policy Blog

NOVEMBER 15, 2024

Very few opioid detections involved fentanyl or fentanyl analogs ( n =6), all of which were reported in 2005 and 2015. Overall, just six items (0.1 %) contained cannabinoids, and opioids were detected in only 23 items (0.5 %).

Marketing 52

Marketing Pharmaceuticals Drugs 52

The Pharma Data

NOVEMBER 10, 2020

The draft resolution renews the commitment to better prepare for health emergencies such as COVID-19, through “full” compliance with the International Health Regulations (2005). In a year that has seen more than 1.2 R10 , at the resumed 73rd World Health Assembly.

International 52

International Compliance Regulations Government 52

Drug Target Review

FEBRUARY 12, 2024

I became a Director in 2005, responsible for the business’s continued growth from 7 initial founding members to 110 employees today. Communication was key – you can have the best technical team in the world, but without the right exposure they remain undiscovered, and it was important to get the message out there.

International 111

International Science Laboratories Pharmaceuticals 111

The Pharma Data

OCTOBER 23, 2020

A pharmaceutical consultant at RMJ Consulting from 2008 to 2009, he found success as the vice president of global quality at Wyeth/FDAH from 2005 to 2008, the director of the Corporate Quality Center of Excellence of Abbott from 2001 to 2005, the director of corporate quality technology at Alcon Laboratories, Inc.,

Pharmaceuticals 52

Pharmaceuticals International Engineering Science 52

The Pharma Data

JANUARY 15, 2021

Marta Laskowski, from the University of Gothenburg in Sweden, and colleagues examined the association between cardiorespiratory fitness and risk for onset of psoriasis and psoriatic arthritis in a cohort of Swedish men in compulsory military service between 1968 and 2005.

Disease 52

Disease Research 52

The Pharma Data

DECEMBER 30, 2020

from Drexel University in Philadelphia, and colleagues used data from 26,818 adult participants in the 2005 to 2018 U.S. WEDNESDAY, Dec. 14 in the American Journal of Preventive Medicine. Langellier, Ph.D., National Health and Nutrition Examination Survey to examine how allostatic load changes over time.

Research 52

Research 52

The Pharma Data

MAY 26, 2023

Since 2005, there has been a nearly 20% increase in tobacco farming land across Africa. Farmers are exposed to chemical pesticides, tobacco smoke and as much nicotine as found in 50 cigarettes – leading to illnesses like chronic lung conditions and nicotine poisoning,” said Dr Ruediger Krech, Director of Health Promotion at WHO.

Government 52

Government Disease 52

Alta Sciences

OCTOBER 9, 2024

Since 2005, the PharmaVoice 100 has become one of the publication’s most anticipated features. Each winner represents progress toward a healthier future for everyone that is bolstered by science and technological advancements.

Clinical Pharmacology 40

Clinical Pharmacology Drug Development Science Clinical Trials 40

New Drug Approvals

SEPTEMBER 8, 2024

. “MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin” The Journal of Clinical Endocrinology and Metabolism. 96 (9): 2889–2897. doi : 10.1210/jc.2011-1061. FDA” (Press release).

FDA 62

FDA Licensing Licensing FDA Approval 62

The Pharma Data

NOVEMBER 20, 2020

from the University of California Davis School of Medicine in Sacramento, and colleagues determined the cumulative incidence of VTE and major bleeding using California hospitalization data for 992 PCNSL patients using the California Cancer Registry (2005 to 2014). Anjlee Mahajan, M.D., percent, respectively. and 1.56, respectively).

Hospitals 52

Hospitals Therapies Research 52

The Pharma Data

JANUARY 22, 2021

from the University of Kansas City in Kansas, and colleagues conducted a systematic review of all MM randomized clinical trials (RCTs) from 2005 to 2019 to examine reporting of prevalence, eligibility criteria, and outcomes of patients with RI and MM. FRIDAY, Jan. 8 in Leukemia & Lymphoma. Ghulam Rehman Mohyuddin, M.D.,

Clinical Trials 52

Clinical Trials Trials Disease Pharmaceuticals 52

FDA Law Blog: Drug Discovery

JUNE 11, 2023

This Draft Guidance, in part, replaces a 2005 guidance titled “How to Comply with the Pediatric Research Equity Act.”

FDA 40

FDA Drug Development Production Drugs 40

The Pharma Data

NOVEMBER 24, 2020

Renal Data System (2005 through 2014) to identify women who for the entire year were aged 15 to 44 years, on dialysis, and with Medicare as the primary payer. TUESDAY, Nov. 24, 2020 — Contraceptive use is low among women of reproductive age undergoing dialysis for end-stage kidney disease, according to a study published online Oct.

Disease 52

Disease Research 52

The Pharma Data

JANUARY 15, 2021

Screening receipt remained below targets for breast and cervical cancer, with little change from 2005 to 2018. The researchers found that colorectal cancer test receipt neared the national Healthy People 2020 target in 2018 (66.9 percent of adults aged 50 to 75 years up to date with testing compared with target of 70.5 © 2021 HealthDay.

Disease 52

Disease Research 52

The Pharma Data

DECEMBER 7, 2020

from Brigham and Women’s Hospital in Boston, and colleagues searched electronic medical records from six hospitals for isolated ulnar fractures in women aged 18 to 50 years from 2005 to 2019. Bharti Khurana, M.D., Radiographs were reviewed to determine fracture location, comminution, and displacement, as well as associated injuries.

Hospitals 52

Hospitals Research 52

The Pharma Data

NOVEMBER 20, 2020

Similarly, more were trying to lose weight in 2015 versus 2005 (42.2 The researchers found that in 2015, 44.4 percent of participants had dieted and 60.5 percent had exercised to lose weight versus 37.7 percent, respectively, in 1986. to 2.59; lifetime dieting in girls: odds ratio, 1.23; 95 percent confidence interval, 0.91 to 1.66).

Research 52

Research 52

The Pharma Data

OCTOBER 15, 2020

Roxanne Gal, from the University of Utrecht in the Netherlands, and colleagues examined the association between automated CAC measurement on RT-planning CT scans and the risk for CVD in a cohort of breast cancer patients receiving RT between 2005 and 2016. Data were included from 14,002 patients (mean age, 58 years).

Disease 52

Disease Research 52

Drug Target Review

APRIL 9, 2024

In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since. Oscar Fernandez-Capetillo did his PhD in the University of The Basque Country working with mouse models of autoimmunity with Dr Ana Zubiaga.

RNA 64

RNA Cell Biology Clinical Development DNA 64

The Pharma Data

SEPTEMBER 23, 2020

In 2005, it cleared an anthrax vaccine for military personnel who were at high risk of being exposed to an anthrax attack. Back in July, the agency said that any vaccine would have to be 50% more effective compared to a placebo. . The FDA has only granted Emergency Use Authorization for a vaccine once before.

Vaccine 52

Vaccine FDA FDA Approval Clinical Trials 52

Drug Target Review

FEBRUARY 7, 2024

Wong represented the US in the NSF-MEXT US-Japan Young Scientist symposium on Nanobiotechnology (2005), the Taipei Academia Sinica International Workshop on Soft Matter and Biophysics (2007), and the NSF-DST US-India Nanoscience & Engineering Workshop (2008). He currently serves on the Editorial Board of Physical Review E.

RNA 69

RNA Virus Immune Response Engineering 69

The Pharma Data

DECEMBER 16, 2020

Yajun Liang, Ph.D., The researchers found that the fully adjusted hazard ratio of dementia was 0.25

Research 52

Research 52

The Pharma Data

NOVEMBER 27, 2020

Researchers analyzed data from more than 1 million children born in England in 2005 and 2006. But researchers said it has been unclear when the risk begins to drop or how it’s affected by a child’s gestational age at birth. On average, they were followed until they were just over 9 years old.

Hospitals 52

Hospitals Research 52

Agency IQ

NOVEMBER 10, 2023

Finally, a third regulation, Regulation (EC) No 2049/2005 , provides for reduced fees for small and medium-sized businesses (SMEs). Amendments in 1999 and 2005 aimed to ensure that EMA’s costs for the services it provides were adequately covered. literature monitoring), since national regulators charge their own fees.

Regulations 40

Regulations Pharmaceuticals Government Therapies 40