article thumbnail

How nucleolar stress accelerates aging in mice

Drug Target Review

In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since. Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects.

RNA 64
article thumbnail

Discovering an Antimalarial Drug in Mao’s China

Codon

It was only in 2005, after the emergence of widespread resistance of P. When Louis Miller, now Chief of Malaria Cell Biology at the NIH, attended a malaria conference in Shanghai in 2008, he asked: Who discovered artemisinin? Few journal articles were written about the project using her (or anyone’s) name before 2010.

Drugs 126
article thumbnail

Precision Medicine in the Genomic Era

DrugBank

Conclusion Since the first GWAS was published in 2005, there have been more than 50,000 significant variant-trait associations identified. Network expansion of genetic associations defines a pleiotropy map of human cell biology. 53 , 1527–1533 (2021).  Barrio-Hernandez, I. 55 , 389–398 (2023).

Disease 88
article thumbnail

Neurobiology & Organismal Biology

Broad Institute

Here we propose to uncover the cell-type specific transcriptional pathways governed by cortisol levels in the frontal cortex, which comprises brain areas that are determinants of high-level cognition and mood, and therefore relevant to the symptomology of PTSD. in molecular and cell biology and biochemistry from the University of Oxford.

article thumbnail

The Codon Guide to Synthetic Biology

Codon

” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Nature (2005). Link →A brief history of synthetic biology , by Cameron D.E. Link Synthetic biology: applications come of age , by Khalil A.S. & Nature Reviews Molecular Cell Biology (2009).

DNA 90
article thumbnail

The Codon Guide to Synthetic Biology

Codon

” Foundations Basics of Synthetic Biology →Foundations for engineering biology , by Endy D. Nature (2005). Link →A brief history of synthetic biology , by Cameron D.E. Link Synthetic biology: applications come of age , by Khalil A.S. & Nature Reviews Molecular Cell Biology (2009).

DNA 52