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In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since. Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cellbiology, mouse models and drugdevelopment projects.
The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drugdevelopment to the point of treatment and continuing patient care.
It was only in 2005, after the emergence of widespread resistance of P. falciparum to monotherapy with conventional drugs like chloroquine and sulfadoxine-pyrimethamine, that the WHO recommended treating malaria with drugs in combination with artemisinin. Meanwhile, on the other side of the Pacific, the U.S.
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