2006 FDA Approval Metabolic Stability Trials 
Metabolite Tales Blog
JULY 5, 2023
Metabolism of de novo-designed macrocyclic drugs approved by the FDA By Julia Shanu-Wilson To date, only 4% (67) of FDA approved drugs are macrocycles [1]. Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. link] [13] A user’s guide to lorlatinib. Nagasaka et al.,
Metabolite Tales Blog
JULY 5, 2023
Metabolism of de novo-designed macrocyclic drugs approved by the FDA By Julia Shanu-Wilson To date, only 4% (67) of FDA approved drugs are macrocycles [1]. Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. link] [13] A user’s guide to lorlatinib. Nagasaka et al.,
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