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Metabolism of macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

Metabolism of de novo-designed macrocyclic drugs approved by the FDA By Julia Shanu-Wilson To date, only 4% (67) of FDA approved drugs are macrocycles [1]. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
article thumbnail

Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

Metabolism of de novo-designed macrocyclic drugs approved by the FDA By Julia Shanu-Wilson To date, only 4% (67) of FDA approved drugs are macrocycles [1]. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
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