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The system optimised the molecules that were most likely to succeed in terms of potency, metabolicstability, synthetic accessibility, and more. Prior to founding Insilico, Alex worked in senior roles at ATI Technologies (a GPU company acquired by AMD in 2006), NeuroGNeuroinformatics, and the Biogerontology Research Foundation.
Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. The resulting macrocyclic structure was found to be associated with improved metabolicstability and low propensity for P-gp efflux compared to the acyclic analog [13]. Nagasaka et al.,
Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. The resulting macrocyclic structure was found to be associated with improved metabolicstability and low propensity for P-gp efflux compared to the acyclic analog [13]. Nagasaka et al.,
2006 , 34, 145-51 [link] 3 Drug Metab. 1990, 1034, 233-237 [link] 13 Metabolism of pyrazole in the Rat [link] 14 Drug Metab. 2006, 34,748-755 [link] 15 Drug Metab. Instead, be on the lookout for N -glucuronides. References 1 Chem. 2002, 15, 3, 269–299 [link] 2 Chem. 2017, 30, 1, 13–37 [link] 2a Drug Metab. Food Drug Anal.
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