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Game-changing pan-TEAD inhibitor for solid tumours

Drug Target Review

JUNE 12, 2023

What are the preclinical characteristics of ISM6331, including its efficacy, safety profile, and drug metabolism and pharmacokinetics (DMPK) properties? The system optimised the molecules that were most likely to succeed in terms of potency, metabolic stability, synthetic accessibility, and more.

Metabolic Stability 92
Metabolic Stability Small Molecule Clinical Trials Pharmacokinetics 92
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Metabolism of five membered nitrogen containing heterocycles

Metabolite Tales Blog

MARCH 1, 2023

2006 , 34, 145-51 [link] 3 Drug Metab. 1990, 1034, 233-237 [link] 13 Metabolism of pyrazole in the Rat [link] 14 Drug Metab. 2006, 34,748-755 [link] 15 Drug Metab. 2010, 75, 9, 3141–3143 [link] 22 Clin Pharmacokinet. Instead, be on the lookout for N -glucuronides. References 1 Chem. 2002, 15, 3, 269–299 [link] 2 Chem.

Metabolic Stability 52
Metabolic Stability Pharmacokinetics Drugs Science 52
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