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Game-changing pan-TEAD inhibitor for solid tumours

Drug Target Review

With 13 preclinical candidates and three AI-designed drugs currently undergoing clinical trials, Insilico is spearheading a revolution in cancer treatment and beyond. Can you provide a summary of the key findings and implications of the preclinical studies on ISM6331 for the treatment of advanced solid tumours?

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Metabolism of five membered nitrogen containing heterocycles

Metabolite Tales Blog

9 The evidence here is that treatment with P450 inhibitors removed the toxic effects seen in the compounds of interest. 2006 , 34, 145-51 [link] 3 Drug Metab. 1990, 1034, 233-237 [link] 13 Metabolism of pyrazole in the Rat [link] 14 Drug Metab. 2006, 34,748-755 [link] 15 Drug Metab. References 1 Chem. Food Drug Anal.