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Metabolism of macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Figure 2 Human metabolism of glecaprevir Involvement of gut bacteria Grazoprevir (MK5172) is also used as part of combination therapy to treat chronic hepatitis C. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Figure 2 Human metabolism of glecaprevir Involvement of gut bacteria Grazoprevir (MK5172) is also used as part of combination therapy to treat chronic hepatitis C. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
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