article thumbnail

Cancer metastasis: breakthrough in therapeutic strategies

Drug Target Review

When bound to GRP78, ID2 loses its inhibitory function, leading to increased invasiveness of cancer cells. Implications for cancer therapeutics and beyond These findings have wide-ranging implications for cancer treatment and cell biology research. IOS Press; 2007 [cited 2023 Jul 26]. Available from: [link]

article thumbnail

New molecular insights on medical cannabis

Drug Target Review

Andrew McCarthy Andrew is a Team Leader at EMBL Grenoble since 2007. He has over 25 years of research experience in the application of structural biology techniques to understand protein function at the molecular level. His team mainly studies proteins involved in cell signalling and neuronal development. 2017;2017:1–15.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Engineering the brightest proteins from the depths | BMG LABTECH

BMG Labtech

4 The crystal structure of the luciferase from Renilla reniformis was determined in 2007. 5 The usefulness of bioluminescence as a tool to study biology at the molecular level jump started a search for alternative luciferases, in many cases from other marine organisms that were bioluminescent.

article thumbnail

CAR-NK cells: promising for cancer therapy

Drug Target Review

Professor Alan Trounson AO CEO, Executive Director, Cartherics Alan is the past President of the Californian Institute for Regenerative Medicine (2007-2014), the Californian state’s $3 billion stem cell agency driving research in stem cell biology and facilitating the translation of stem cell discoveries into clinical therapies.

Therapies 117
article thumbnail

TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

article thumbnail

Research Roundup: Different Antibody Responses to COVID-19 and More

The Pharma Data

It is a big improvement over the first reference assembled in 2007, and they believe it can help analyze and answer fundamental questions in molecular genetics, cell biology and physiology, not just in rhesus macaques, but in humans and other primates and mammals.

article thumbnail

First Patient Dosed in Monalizumab Phase 3 Clinical Trial Triggers $50M Payment From AstraZeneca

The Pharma Data

months (Vermorken et al, JCO 2007). Innate has been a pioneer in the understanding of natural killer cell biology and has expanded its expertise in the tumor microenvironment and tumor-antigens, as well as antibody engineering. overall response rate, a median time to progression of 2.3 months and a median overall survival of 5.8