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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We need to build the assays that we need for compound screening. In 2007 Dr van Montfort joined the Institute of Cancer Research (London, UK), where he holds a joint position between the Centre for Cancer Drug Discovery (CCDD) and the Division of Structural Biology.

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Re-assessing the risks of drug-induced arrhythmias during drug discovery

Drug Discovery World

Manual patch-clamping of single cells has become a mainstay of functional electrophysiology, often used to follow up after novel hit compounds are identified by non-functional fluorescence or ligand binding methods, which are considerably higher in their throughput. Scannell et al. 2022) Nature Reviews Drug Discovery, 21: 915–931.

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