Drug Target Review

NOVEMBER 1, 2023

2 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. 1-5 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. Andrew McCarthy Andrew is a Team Leader at EMBL Grenoble since 2007.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

New Drug Approvals

OCTOBER 12, 2024

2007 ; Kocis et al., Alzheon licensed ALZ-801 from NeuroChem and is developing it for Alzheimer’s disease. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease. Clin Pharmacokinet. Tramiprosate was reported to inhibit Aβ42 aggregation into toxic oligomers ( Gervais et al.,

Pharmacokinetics 62

Pharmacokinetics Small Molecule Disease Licensing 62

Agency IQ

SEPTEMBER 15, 2023

In 2007, an FDA advisory committee weighed phenylephrine’s GRASE status, prompted by a Citizen Petition questioning its effectiveness In December 2007, the FDA’s Nonprescription Drugs Advisory Committee met to discuss the efficacy of phenylephrine 10 mg , the oral dosage approved for OTC use.

Science 40

Science FDA Clinical Trials Clinical Pharmacology 40

New Drug Approvals

JANUARY 9, 2024

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. 2007; Ganuza et al., Tacaciclib 2768774-66-7 AUR-102 Tacaciclib SCHEMBL24548621 GTPL12880 528.6 Aug 26;78(4):713- 24, 1994).

Production 62

Production DNA RNA Regulations 62

Advarra

DECEMBER 14, 2022

Effective as of 2007, Medicare has offered coverage for routine costs in clinical trials. The study must have therapeutic intent or aim to treat the disease. Safety, quality of life, and pharmacokinetic (PK) responses are not considered to be therapeutic objectives. The patient must have a diagnosed disease.

Clinical Trials 52

Clinical Trials Trials Compliance FDA Approval 52

Codon

FEBRUARY 23, 2025

When tests showed that zidovudine did not work against cancer, though, Horwitz set it aside — but told his peers that this molecule, as well as similar DNA base mimics, were “a very interesting set of compounds that were waiting for the right disease.” Jerome Horwitz and Wolfram Ostertag.

Clinical Trials 74

Clinical Trials Virus Vaccine DNA 74