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2007; Ganuza et al., CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., Mar 23;25(6):839-50. May 30; 31(11): 2498-510, 2012). 13, 261-91, 1997). Cancer Res. 8, 3527-3538, 2002).
Researcher Jerome Horwitz at the Michigan Cancer Foundation developed it as a potential cancer treatment by chemically-modifying thymine, a DNA building block. Since zidovudine failed to interfere with DNA-to-DNA replication, Ostertag wondered if it could block RNA-to-DNA replication instead.
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