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2,8-10 However, the number of compounds with satisfying pharmacokinetic parameters (PKD) are limited, with most unable to cross the blood-brain barrier or go sufficiently deep into a malignant tumour. Andrew McCarthy Andrew is a Team Leader at EMBL Grenoble since 2007. J Med Chem. 2017 Mar 9;60(5):2006–17. J Med Chem.
2007 ; Kocis et al., ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. Clin Pharmacokinet. Hey JA, et al.
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