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Metabolism of macrocyclic drugs

Metabolite Tales Blog

However, in the quest to tackle challenging disease targets with difficult drug binding sites, there is revived interest in developing this compound type to offer unique solutions. Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders.

Drugs 52
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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

However, in the quest to tackle challenging disease targets with difficult drug binding sites, there is revived interest in developing this compound type to offer unique solutions. Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders.

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Beyond ELISA: the future of biomarker validation

Drug Target Review

5 Alzheimer’s disease: driving advancements with precision medicine In contrast, advanced technologies like MSD and LC-MS/MS offer enhanced precision and sensitivity for biomarker analysis. 2008 Aug 1;63(8):879–84. Clinical Pharmacology & Therapeutics. Biomarker Qualification: Evidentiary Framework [Internet].