NIH Director's Blog: Drug Development

JUNE 14, 2016

People with type 2 diabetes are at increased risk for heart attacks, stroke, and other forms of cardiovascular disease, and at an earlier age than other people. In fact, the evidence suggests that such drugs might even offer some protection against heart disease. December 2008. [2] Food and Drug Administration. Sci Transl Med.

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The Pharma Data

APRIL 10, 2021

Freire is President and Executive Director and member of the board of directors of the Foundation for the National Institutes of Health, a nonprofit organization committed to accelerating biomedical research and advancing breakthrough discoveries to fight critical diseases. About Maria C.

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The Pharma Data

NOVEMBER 4, 2020

A special diet may be a diet to lose weight or one aimed at improving health, such as a lower-carbohydrate diet for someone with diabetes, or avoiding gluten for someone who has Celiac disease. adults have diet-related chronic diseases, such as cardiovascular disease, high blood pressure or type 2 diabetes. 3 in the U.S.

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The Pharma Data

NOVEMBER 20, 2020

20, 2020 (American Heart Association News) — Heart disease and depression are interwoven, and a new study is helping unravel that connection by linking depression with poorer scores on seven important measures of heart health. People with depression are more likely to develop heart disease. FRIDAY, Nov. That is “critical.

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The Pharma Data

MARCH 2, 2021

Senior Vice President and Global Head of Cardiometabolic Diseases Research, Boehringer Ingelheim. Obesity is a complex chronic disease that requires long-term management. It is among the leading risk factors for several cardio-metabolic diseases, such as heart disease, ischemic stroke, liver diseases incl.

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Drug Target Review

FEBRUARY 7, 2024

For example, innate immune peptides being imitated by SARS-CoV-2 fragments have a special ability to organise double stranded RNA into structures that strongly amplify activation of the human innate immune system in autoimmune diseases. He currently serves on the Editorial Board of Physical Review E.

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Drug Target Review

FEBRUARY 28, 2024

Human γδ TCR repertoires in health and disease. Increased frequency of TCR gamma delta + T cells in disease-free survivors following T cell-depleted, partially mismatched, related donor bone marrow transplantation for leukemia. J Immunol 180(9):6044-6053 (2008). References Fichtner A, Ravens S, Prinz I. Cells 9(40):800 (2020).

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The Pharma Data

AUGUST 9, 2020

Pivotal phase III stud y of etrolizumab in Crohn’s disease is ongoing. Roche is studying additional investigational medicines in inflammatory bowel diseases. We are fully analysing these data to learn more about how we might address the needs of people with this devastating disease.

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The Pharma Data

JUNE 28, 2021

There are currently no FDA-approved anticoagulation therapies for pediatric patients with congenital heart disease who have undergone the Fontan procedure. Since launch in 2008, more than 86 million patients have been treated. If approved, Xarelto will be the only oral Factor Xa Inhibitor indicated in the U.S. EINSTEIN-Jr.

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Drug Target Review

SEPTEMBER 20, 2023

From 2005 to 2008 he carried out a DPhil (PhD) at Oxford on nanomaterials for quantum computation, followed by postdoctoral work on the prediction of crystal structures at University College London. Training AI/ML tools to predict results of otherwise complex and time-consuming calculations is gaining traction in pharmaceutical R&D.

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The Pharma Data

NOVEMBER 25, 2020

Vifor Pharma Group strives to help patients around the world with severe and chronic diseases lead better, healthier lives. Even without anemia, iron deficiency can be debilitating, exacerbate an underlying chronic disease and lead to increased morbidity and mortality 4. Nutrition and nail disease. Am J Clin Nutr. Qual Life Res.

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Metabolite Tales Blog

JANUARY 26, 2023

Vonoprazan fumarate, a novel potassium competitive acid blocker, in the management of gastroesophageal reflux disease: Safety and clinical evidence to date. References Iversen et al., Drug metabolism and drug transport of the 100 most prescribed oral drugs. Basic Clin Pharmacol Toxicol. 2022; 131(5): 311- 324. link] Maréchal et al.,

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NIH Director's Blog: Drug Discovery

MAY 9, 2019

Such information will not only expand fundamental biological understanding, but will accelerate efforts to discover new therapies for diseases, such as cancer, in which disruption of allosteric proteins plays a crucial role. 2008 Sep;33(9):420-425. [2] ’ Fenton AW. Trends Biochem Sci.

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Molecule Blog

AUGUST 13, 2021

v=uT2-0qoHjbc Who will be there: Molecule & VitaDAO Core Teams If you haven’t yet read up on the research project as well as the researchers behind it, find more about it below: About the Research Project What if therapeutics to slow down the ageing process and prevent age-related disease already existed?

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The Pharma Data

DECEMBER 17, 2020

The patients were monitored for a median of five years to assess invasive disease-free survival (IDFS) and overall survival (OS). For premenopausal women, our findings mean they can be assured that chemotherapy should, in fact, help them live longer or without their disease spreading,” Kalinsky said. ” Press Release.

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The Pharma Data

SEPTEMBER 30, 2021

by an additional 40 percent effective January 1, 2022, effectively bringing the list price down to 2008 levels. 2 Diabetes may be a chronic disease that happens when the body doesn’t properly produce or use the hormone insulin. Eli Lilly and Company (NYSE: LLY) will lower the list price of Insulin Lispro Injection in the U.S.

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NIH Director's Blog: Drug Development

OCTOBER 11, 2022

Science 2008, 320 (5876), 664–667. [6] Bertozzi: National Cancer Institute; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences 2004, 126 (46), 15046–15047 [5] In vivo imaging of membrane associated glycans in developing zebrafish. Laughlin ST, Baskin JM, Amacher SL, Bertozzi CR.

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The Pharma Data

OCTOBER 15, 2020

John Hospital, researchers compared 649 patients from two cohorts: a recent cohort (2017–2019) from the RECOVER III post-market approval (PMA) study, after the widespread adoption of the best practice of placing Impella pre-PCI, and a cohort from before PMA (2008–2014) when the practice of placing Impella pre-PCI was not yet widely adopted.

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Codon

JUNE 11, 2024

Biologists use nanopores for everything from diagnosing diseases and monitoring changes within rainforest ecosystems to discovering proteins from microbes frozen in Icelandic glaciers. Such a device seems implausible. But these little machines, small enough to fit inside a pocket, have become commonplace.

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The Pharma Data

DECEMBER 17, 2020

Most recently, Cadavid served as senior vice president and Head of Clinical Development at Fulcrum Therapeutics where he led the development of multiple small molecules for the treatment of genetically defined rare diseases. She joined VMS BioMarketing in 2008 and has served as its president and CEO since 2011.

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Metabolite Tales Blog

JULY 5, 2023

However, in the quest to tackle challenging disease targets with difficult drug binding sites, there is revived interest in developing this compound type to offer unique solutions. Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders.

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Metabolite Tales Blog

JULY 5, 2023

However, in the quest to tackle challenging disease targets with difficult drug binding sites, there is revived interest in developing this compound type to offer unique solutions. Current macrocycles in clinical use generally focus on treatment of infectious diseases, cancer and auto-immune disorders.

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The Pharma Data

NOVEMBER 5, 2020

Prior to Akcea, she was senior vice president and General Manager of Cardiometabolic and Rare Disease Businesses and Strategic Alliances at Moderna, Inc. Prior to joining Navitor, Hughes served as president and CSO of Zafgen and previously led Zafgen as CEO from 2008 to 2017. Schijns, a former professor at N.C.

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Agency IQ

APRIL 19, 2024

As the FDA’s Center for Drug Evaluation and Research (CDER) characterized it in a 2023 call for comments : “Evolving understanding of disease biology and molecular pharmacology, advancements in drug discovery, and growth in novel therapeutic platforms (i.e., KEVIN BUGIN will serve as C3TI Director.

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Agency IQ

JUNE 7, 2024

The PPPR framework governs the authorization, sale, and use of PPPs, establishing a pre-market approval process for active substances – the pesticide components which control pests, weeds, and plant diseases – and for synergists and safeners before they can be allowed for use in PPPs.

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Agency IQ

JUNE 7, 2024

23 MDS 1003 Devices manufactured utilising tissues or cells of animal origin, or their derivatives Section 5.3.2

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Agency IQ

NOVEMBER 27, 2023

A 2008 survey from FDA’s Division of Drug Marketing, Advertising and Communications (DDMAC) – the successor to its Office of Prescription Drug Promotion (OPDP) – found that 10 of 30 randomly selected television advertisements would have violated FDA’s proposed standards.

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Drug Target Review

JANUARY 15, 2024

Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is the third leading cause of global deaths. The Pathology of Chronic Obstructive Pulmonary Disease. Annual Review of Pathology: Mechanisms of Disease. 2008 October 27 [2024 January 5]; 4:435-459. References 1 Hogg JC, Timens W.

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Codon

APRIL 9, 2024

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In this light, scouring old Chinese remedies for new treatments for a disease specifically troublesome during war was entirely intuitive for Chinese biomedical scientists like Tu Youyou in the mid-20th century.

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The Pharma Data

MAY 14, 2021

Products are not intended to diagnose, treat, cure or prevent any disease. Barton Publishing since 2008 and is paid for his work. Products are not intended to diagnose, treat, cure or prevent any disease. Delivering Hope & Healing, Since 2004. If you are. before using our products. Results may vary. If you are.

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The Pharma Data

JUNE 30, 2021

Every year, the ABCD gives out this prize, which Boehringer Ingelheim is sponsoring since its creation in 2008. This could allow clinicians to rapidly identify regressively infected cats that are unlikely to develop FeLV-related disease. To foster young talent development in the feline health research community. References.

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New Drug Approvals

SEPTEMBER 29, 2024

gingivalis has been called a risk factor for Alzheimer’s disease ( Kanagasingam et al., gingivalis is associated with cardiovascular disease. In aged dogs with periodontal disease, ninety days of COR388 reduced oral bacterial load and gum pathology ( Arastu-Kapur et al., Cortexyme’s approach is based on the theory that P.

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Drug Target Review

OCTOBER 26, 2023

1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Journal of virology 82 , 5887-5911 (2008). Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. Grimm D, et al.

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PLOS: DNA Science

MARCH 21, 2024

Lenmeldy adds functional genes that encode the enzyme arylsulfatase A (ARSA) to bone marrow stem cells taken from children who have inherited the disease, but haven’t yet developed symptoms, which typically begin around age 2 or 3. Liviana was born in January 2008 in Omaha, Nebraska, and diagnosed with MLD in December 2010.

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The Pharma Data

MARCH 30, 2021

Martin, PhD, who served as the company’s chief executive officer from 1996 to 2016 and as its chairman from 2008 to 2019. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead Sciences, Inc. Source link:[link].

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The Pharma Data

JANUARY 26, 2021

Prediabetes can be reversed, and smaller studies suggest doing so lowers the risk of developing heart disease. Their blood sugar was checked in 2006, and again in 2008, and they were tracked through 2017. Between 2006 and 2008, about 45% of the participants reverted from prediabetes to normal blood sugar.

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Common Sense for Drug Policy Blog

JULY 8, 2023

Additionally, the framing of Portuguese drug addiction as a ‘disease’ is somehow pathologizing and might undermine the right to agency and self-determination of people using drugs, who still experience stigma, discrimination and sometimes violence from police, service and health-care providers and the community at large [ 7 ].

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