Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Journal of virology 82 , 5887-5911 (2008).

Engineering 105

Engineering Virus Therapies Immune Response 105

PLOS: DNA Science

AUGUST 22, 2024

When Crichton died of cancer in 2008, he left behind a staggering trove of research about an eruption of Mauna Loa on the Big Island of Hawaii. Unforgettably, my daughter Heather threw up on the volcano, an early sign of gallbladder disease and to this day, her claim to fame. The DNA double helix is exquisitely symmetrical.

DNA 68

DNA Virus Organic Chemistry Science 68

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. After copying the DNA to form a big pool, each piece is sequenced.

DNA 107

DNA Laboratories Hospitals Virus 107

New Drug Approvals

APRIL 5, 2025

9] In the body, treosulfan is converted into other compounds called epoxides which kill cells, especially cells that develop rapidly such as bone marrow cells, by attaching to their DNA while they are dividing. [9] 9] It belongs to the family of drugs called alkylating agents. [9] 9] Efficacy was evaluated in MC-FludT.14/L

FDA 62

FDA FDA Approval Production Treatment 62

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2008). Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. & Shamir R. Artificial Life (2018).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

PLOS: DNA Science

FEBRUARY 3, 2025

Karen died on November 16, 2008 – coincidentally, the same date that Dr. Liebman’s father had died 28 years earlier, at age 66, from a presumed heart attack. So she contacted Dr. Elizabeth McNally, a specialist in genetic heart disease at the University of Chicago. Her doctor said this was because she was 6 months pregnant.

Disease 80

Disease DNA Doctors Science 80

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2008). Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. & Shamir R. Artificial Life (2018).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

FEBRUARY 9, 2025

” Indeed, Gage’s case initiated a standard practice in neuroscience in which diseased or damaged brains are used to examine the connection between behavior and neuroanatomy — a method referred to as “ lesion studies.” Amazingly, Gage not only survived but is remembered as “the man who began neuroscience.”

Research 110

Research Disease Engineering Regulations 110