Codon
FEBRUARY 13, 2025
One study from 2008 (also from the Baker lab) reported de novo enzyme catalysts for Kemp elimination — a reaction that opens up a benzisoxazole ring — by running molecular dynamics simulations to sieve through possible designs. They synthesized DNA encoding each protein variant, expressed the proteins in E.
Drug Target Review
NOVEMBER 13, 2023
The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Another finding was that regulatory T cells had distinct chromatin architecture features called DNA loops. Nature reviews immunology [Internet] 2008 July [2023 November 10]; 8:523-32.
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Codon
JUNE 11, 2024
And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.
Broad Institute
AUGUST 25, 2023
Together, our researchers and collaborators have harnessed and advanced DNA mapping and sequencing technologies, and have assembled the world’s largest collection of DNA samples in psychiatric research — including samples for schizophrenia, bipolar disorder, other psychiatric disorders, and healthy control samples.
The Pharma Data
DECEMBER 17, 2020
She assists both patients and physicians in completing this revolutionary gene test that determines if a patient is on the right drug, at the right dose, for their specific DNA. After relocating to Montgomery, Alabama, she retained this title and its responsibilities at Jackson Hospital from 2008 to 2015.
Molecule Blog
AUGUST 13, 2021
In 2008, he became a Postdoctoral Fellow at the National Institute on Aging at the NIH in Baltimore, Maryland. His work focused on the cross-talk between DNA repair and mitochondrial function in aging and has been honored by a number of competitive awards. He now runs one of the largest research programmes in Europe focusing on aging.
DrugBank
JUNE 27, 2023
In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., 9 , 477–485 (2008). Coding mutations have a more direct effect through direct alteration of a gene product. by altering its accessibility to transcriptional machinery). 12 , 713230 (2021).
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