New Drug Approvals

DECEMBER 3, 2022

Because many cancers have mutations in these genes that allow them to survive, scientists began working to develop drugs that would inhibit this pathway in the 1990s. [1] 2008): 360–367. Hann CL, Daniel VC, Sugar EA, Dobromilskaya I, Murphy SC, Cope L, Lin X, Hierman JS, Wilburn DL, Watkins DN, Rudin CM (April 2008).

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Drug Target Review

SEPTEMBER 26, 2023

CNS-related issues account for nearly a quarter of failures during clinical development, a phase where consequences are high in terms of resources and patient impact. CNS-related issues account for nearly a quarter of failures during clinical development, a phase where consequences are high in terms of resources and patient impact.

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Conversations in Drug Development Trends

APRIL 5, 2024

Observed annually on the last day of February since 2008, Rare Disease Day has grown into a global movement for raising awareness, promoting research, and advocating for improved access to rare disease treatments and support services. For others, this rare day is aptly the day we honor rare disease communities.

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Perficient: Drug Development

OCTOBER 4, 2023

PROJECT BACKGROUND Since 2008, Perficient has delivered multiple infrastructure platforming, commerce, and management consulting projects for this multinational corporation. In early 2021, our Life Sciences experts presented a Clinical Data Review Platform (CDRP) that demonstrated our strong industry perspective and expertise.

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Perficient: Drug Development

JUNE 25, 2024

Learning from history, he referenced the lack of regulatory controls in derivatives and financial engineering before the 2008 financial crisis, and more recently, the unregulated growth of cryptocurrencies leading to the “Crypto Winter” of 2022.

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Perficient: Drug Development

AUGUST 16, 2023

He was promoted to President and CEO in 2008. Shan Hanes, who served as the bank’s President and CEO until its closure, joined the firm in 1993 as an agricultural loan officer and Informational Technology Officer.

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NIH Director's Blog: Drug Development

OCTOBER 11, 2022

2004, 126 (46), 15046–15047 [5] In vivo imaging of membrane associated glycans in developing zebrafish. Science 2008, 320 (5876), 664–667. [6] Laughlin ST, Baskin JM, Amacher SL, Bertozzi CR. 6] Small molecule inhibitors of mucin-type O-glycosylation from a uridine-based library. 2004 Jul;11(7):1009-1016.

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Perficient: Drug Development

JANUARY 23, 2024

As a long-time Sitecore practitioner (since 2008!), witnessing the evolution of Sitecore development over the years has been fascinating. With Sitecore’s transformation from a web CMS into a comprehensive martech suite, the role of a Sitecore developer has undergone a significant shift.

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Perficient: Drug Development

JUNE 14, 2023

Our healthcare practice incubated out of the Chicago team in 2008, originally focusing on data analytics and warehouses. John and his wife, Merri I have been with Perficient for 19 years. In 2002, Perficient acquired the small technology company I was working for in Chicago.

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Agency IQ

APRIL 19, 2024

As the FDA’s Center for Drug Evaluation and Research (CDER) characterized it in a 2023 call for comments : “Evolving understanding of disease biology and molecular pharmacology, advancements in drug discovery, and growth in novel therapeutic platforms (i.e., Read AgencyIQ’s full analysis of that meeting here.]

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Perficient: Drug Development

MARCH 15, 2024

A few BYD highlights: BYD has outsold VW, formerly the best-selling brand in China BYD has Warren Buffet Berkshire Hathaway backing Berkshire Hathaway took a 10% stake in BYD in 2008 for $232 million.

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DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care. 12 , 713230 (2021).

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Agency IQ

OCTOBER 6, 2023

According to the Substance Abuse and Mental Health Services Administration (SAMHSA), “between 2008 and 2015, amphetamine-related hospitalizations more than tripled, increasing from 55,447 instances to 206,180. Regulatory context FDA held a workshop in December 2019 to discuss development of substance use disorder therapies.

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Codon

APRIL 9, 2024

Department of Defense administered mefloquine, the synthetic drug developed at Walter Reed in the U.S., only issued “the strongest ‘black box’ warning” against the drug in 2013. have been poured into replicating work already done” by Chinese scientists decades ago. Nobody had an answer.

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Drug Target Review

JANUARY 16, 2025

Advanced Drug Delivery Reviews , 64:417, 2012. The exploration of macrocycles for drug discovery: An underexploited structural class. Nature Reviews Drug Discovery , 7(7):608624, 2008. Driggers EM, Hale SP, Lee J, Terrett NK. Dougherty PG, Qian Z, Pei D. Macrocycles as protein-protein interaction inhibitors.

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Drug Target Review

NOVEMBER 27, 2024

Introduction Biomarkers are becoming increasingly essential in drug development and clinical practice, driving the need for more precise validation methods. Given this, what’s holding drug developers back? Advanced techniques like MSD and LC-MS/MS offer unmatched precision and sensitivity at a fraction of the cost.

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Alta Sciences

MARCH 4, 2025

Over time, this group of professionals evolved and grew, having regular stakeholder interactions with the FDA and Controlled Substances staff to discuss requirements for drug developers. I have spent the better part of my career working to make drugs safer. About the Author Beatrice Setnik, PhD, Chief Scientific Officer.

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Conversations in Drug Development Trends

NOVEMBER 13, 2024

Despite another kidney infection in the first year, I graduated early in December 2008. I canceled a planned summer study abroad to focus on my health but managed to study in Seville, Spain, that fall. In 2011, I participated in a Type 1 diabetes clinical trial and have continued exploring study opportunities ever since.

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Perficient: Drug Development

OCTOBER 24, 2024

Learning from history, he referenced the lack of regulatory controls in derivatives and financial engineering before the 2008 financial crisis, and more recently, the unregulated growth of cryptocurrencies leading to the “Crypto Winter” of 2022.

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Regulations Compliance Engineering Marketing 52

Perficient: Drug Development

NOVEMBER 30, 2024

The proper CSP directives can now take the place of X-frame-options, which are a holdover from 2008. These are the most important HTTP security headers, while there are more, such public-key-pins and X-XSS-protection. Publishers can prevent intruders from utilising their material in an unseen frame by using this header.

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Drug & Device Law

OCTOBER 10, 2022

3 (2008), the court explained that “the word ‘includes,’ when used in a statute, ‘is usually a term of enlargement, and not of limitation.’” Pfizer, Inc. , Finally, the decision highlights a current conundrum with respect to modern drug development. Not so, said the court. Quoting the Supreme Court in Burgess v. 124, 131 n.3

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Drug & Device Law

JULY 21, 2022

Citing various examples of live-saving drugs developed with animal testing, NABR noted that “[t]he vital role of animal research in advancing medicine cannot be overstated.” Under New York law as under federal law, judges are required to recuse themselves when their “impartiality might reasonably be questioned.” 2d 14, 16 (N.Y.

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