Drug Target Review

SEPTEMBER 26, 2023

Early detection of neurotoxicity induced by potential new therapies is a major challenge, and hiPSC-neuronal cells may provide a solution. 2009 Sep;14(17–18):876–84. Human derived induced pluripotent stem cells (hiPSCs) have revolutionised research and are increasingly used for toxicology screening and disease modelling.

Drugs 111

Drugs FDA Disease Animal Testing 111

Codon

JULY 21, 2024

It may seem that if researchers are sufficiently concerned about the welfare of lab animals, the best thing to do would be to stop using animals altogether. However, a multitude of factors—from institutional inertia to a global animal-testing industry worth billions of dollars —make this outcome unlikely.

Research 122

Research Engineering Disease Science 122

Codon

MARCH 14, 2023

In 2009, a small group of Dutch biologists rounded up some lab mice, stabbed them with needles, and harvested their blood. Mice and rats account for 95 percent of all animals used in biomedical research. For every 5,000 drug compounds tested in mice, five move into human studies. Each animal had a different microbiome.

DNA 52

DNA Laboratories Engineering Animal Testing 52