Drug Target Review

JUNE 29, 2023

It set a precedent with regulators as to what is expected in some instances. Because we are using cells as medicines, they’re living medicines that we hope that they become cancer treatments where it’s literally one dose and you’re done.

Therapies 115

Therapies Science Production Cell Biology 115

DrugBank

JUNE 27, 2023

14 As an unbiased method for genetic variant detection, GWAS holds the promise of identifying new genes and gene regulation mechanisms underlying a variety of conditions, including complex diseases. 5 , e1000433 (2009). Network expansion of genetic associations defines a pleiotropy map of human cell biology. PLoS Genet.

Disease 98

Disease Treatment Drugs Clinical Trials 98

Codon

APRIL 9, 2023

Read Probe-based bacterial single-cell RNA sequencing predicts toxin regulation. Current Biology. ACS Synthetic Biology. A programmable and red light-regulated CRISPR-dCas9 system for the activation of endogenous genes in Saccharomyces cerevisiae. ACS Synthetic Biology. Nature Cell Biology.

Therapies 52

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New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Broad Institute

JULY 28, 2023

Our pilot study will span: 1) high-resolution EM (electron microscopy) of synaptic excitatory-inhibitory (E-I) balance and nearby glial cells; 2) functional electrophysiological signatures of altered E-I balance by sex in ACC brain slices; 3) molecular correlates of these impairments that can be targeted for recovery of function.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

BMG Labtech

FEBRUARY 24, 2025

Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. For example, it may result in changes to cell metabolism or lead to alterations in crucial signaling events. doi: 10.1073/pnas.0307446101.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

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