Broad Institute
APRIL 5, 2025
Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. Liu became an HHMI investigator in 2005 and joined the JASONs, academic science advisors to the US government, in 2009.
The Pharma Data
DECEMBER 11, 2020
The researchers said the technique could break the cycle of disease passed from mother to baby through mutations in mitochondrial DNA (mtDNA). The researchers said the first five monkeys born in 2009 at OHSU’s Oregon National Primate Research Center with the aid of the technique all developed normally to adulthood.
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The Open Targets Blog
APRIL 25, 2023
via Wikimedia Commons) Right: Copy of a DNA sequence faxed in 1989 from teams working on the Human Genome Project (from the Wellcome Collection archives, Image credit: Helena Cornu) Assembling a team At the core of this of course were people to provide both the intellectual input and the perseverance to make things happen. MORRISON, K.
The Pharma Data
OCTOBER 21, 2020
INSTIs, like cabotegravir, inhibit HIV replication by preventing the viral DNA from integrating into the genetic material of human immune cells (T-cells). This step is essential in the HIV replication cycle and is also responsible for establishing chronic infection. About ViiV Healthcare.
DrugBank
JUNE 27, 2023
In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., 5 , e1000433 (2009). Coding mutations have a more direct effect through direct alteration of a gene product. by altering its accessibility to transcriptional machinery). PLoS Genet. Ozbek, U. &
New Drug Approvals
JANUARY 9, 2024
Nature Cell Biology, 11, 1275 – 1276, 2009), whilst different tumors appear to require some, but they are independent of other interphase CDKs (CDK2, CDK4 , CDK6). CDK7 also plays a role in transcription and possibly in DNA repair. 27, 6012-6018, 2009; Christian et al., 3, S179-S185, 2009). Mar 23;25(6):839-50.
Agency IQ
OCTOBER 12, 2023
In particular, they discussed the potential for genotoxicity, or the potential to damage human DNA, and developmental neurotoxicity, or the negative effect on the developing human nervous system. These experts concluded that there were real concerns regarding the human health risk of chlorpyrifos and CHP-methyl.
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