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Metabolism of five membered nitrogen containing heterocycles

Metabolite Tales Blog

Bicyclic structures containing five membered rings such as indoles, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring, are also increasingly relevant as growing research fields such as psychedelics make use of these scaffolds, often found in natural products. 2009, 41, 157-167 [link] 19 Molecules.

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Efficient trajectories

Molecular Design

The heavy citation and wide acceptance of Ro5 provided incentives for researchers to publish their own respective analyses of large (usually proprietary) data sets and this has been expressed more succinctly as “Ro5 envy”. So let's take a look at YL2018 and the trajectories.