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Target-directed cancer: protein-ligand interactions  

Drug Target Review

In 2007 Dr van Montfort joined the Institute of Cancer Research (London, UK), where he holds a joint position between the Centre for Cancer Drug Discovery (CCDD) and the Division of Structural Biology.

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Variability in biological activity measurements reported in the drug discovery literature

Molecular Design

When examining differences between IC 50 values for the same combination of target and inhibitor it's worth bearing in mind that interference with assay read-outs tends to be more of an issue at high concentration (this is why biophysical assays tend to be favored for screening fragments).