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As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,
Nature Reviews Genetics (2010). Link Is the cell really a machine? , Journal of Theoretical Biology (2019). Link The second wave of synthetic biology: from modules to systems , by Purnick P.E.M. & Nature Reviews Molecular CellBiology (2009). Nature Reviews Molecular CellBiology (2014).
Nature Reviews Genetics (2010). Link Is the cell really a machine? , Journal of Theoretical Biology (2019). Link The second wave of synthetic biology: from modules to systems , by Purnick P.E.M. & Nature Reviews Molecular CellBiology (2009). Nature Reviews Molecular CellBiology (2014).
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