PLOS: DNA Science

MARCH 21, 2024

Lenmeldy adds functional genes that encode the enzyme arylsulfatase A (ARSA) to bone marrow stem cells taken from children who have inherited the disease, but haven’t yet developed symptoms, which typically begin around age 2 or 3. Liviana was born in January 2008 in Omaha, Nebraska, and diagnosed with MLD in December 2010.

Therapies 97

Therapies Clinical Trials DNA Trials 97

PLOS: DNA Science

MAY 25, 2023

Myotonic dystrophy type 1 (DM1), an inherited disease affecting muscles, was one of the first described “expanding repeat” disorders. In these 50 or so conditions, symptoms may appear earlier and worsen from generation to generation, as the mutant gene grows, adding copies of a 3- or 4-base DNA sequence.

Treatment 52

Treatment DNA RNA Clinical Trials 52

Drug Target Review

AUGUST 9, 2023

Published on bit.bio’s website, this article authored by Dr Tony Oosterveen dives into the close relationship between FTD and ALS with a focus on mechanisms underlying the neuropathology of both diseases. ALS is the most common motor neuron disease and is estimated to affect more than 80,000 people worldwide.

RNA 98

RNA Regulations Disease DNA 98

PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. The Likely Predecessor of SARS-CoV-2 – From my Past Blog Posts I wrote 100+ DNA Science blog posts during the pandemic about the virus.

Virus 52

Virus RNA DNA Science 52

Codon

JUNE 18, 2024

Dr. Karl Dussik, an Austrian physician, was among the first to suggest that ultrasound could be used to diagnose diseases within the body in 1941. Right) The passage of text from a 2010 review that inspired Mikhail Shapiro to engineer gas vesicles. Voigt, Biotechnology Journal (2010). But ultrasound is different. megaterium.

Engineering 67

Engineering Laboratories International Clinical Trials 67

Codon

JULY 27, 2023

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. They’re talking about a patient who has a rare genetic disease. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. From Sulis D.B. in Science.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. They’re talking about a patient who has a rare genetic disease. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. From Sulis D.B. in Science.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

FEBRUARY 27, 2024

Most square centimeters of our built environments transmit next to no disease (think of walls, which we rarely so much as brush in passing), but some are touched with extraordinary frequency. Diarrheal diseases—attributed to viruses, such as noroviruses, which are spread via fomite transmission—killed about 1.5

Virus 70

Virus Hospitals Production Regulations 70

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. This was the founding ethos of Moderna, the mRNA vaccine developer, when it was launched in 2010 by Noubar Afeyan and Doug Cole at Flagship Pioneering. “It was about 6 p.m.

Engineering 86

Engineering Vaccine Production RNA 86

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering Therapies RNA 52

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

RNA 103

RNA DNA Vaccine Virus 103

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

APRIL 24, 2025

We’re close to selling out of our second book —written in both text and DNA—and we recently launched a merchandise store. By analyzing how enrollment rates respond to changes in policy, funding, and disease targets, we can see which approaches most effectively accelerate pharmaceutical innovation. How did they do it?

Clinical Trials 70

Clinical Trials Trials Pharmaceutical Companies Licensing 70

Codon

AUGUST 10, 2023

Nature Reviews Genetics (2010). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link Next-Generation DNA Sequencing Methods , by Mardis E.R.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Nature Reviews Genetics (2010). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Drug Discovery Today: Disease Models (2008). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link Next-Generation DNA Sequencing Methods , by Mardis E.R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

FEBRUARY 9, 2025

” Indeed, Gage’s case initiated a standard practice in neuroscience in which diseased or damaged brains are used to examine the connection between behavior and neuroanatomy — a method referred to as “ lesion studies.” Amazingly, Gage not only survived but is remembered as “the man who began neuroscience.”

Research 110

Research Disease Engineering Regulations 110

Codon

MARCH 16, 2025

I didn’t learn about them until the summer of 2010, when in examining my motivations to pursue a career in biomedical research, I started looking for explanations behind my mother’s disease. Today, decades after the invention of DNA sequencing, it is easy to take the accessibility of genomic data for granted.

DNA 117

DNA Disease Medical Schools Hospitals 117

Codon

FEBRUARY 23, 2025

Countries supported by PEPFAR saw HIV cases drop by 52 percent in 2023 compared to 2010, outpacing the 39 percent global decline. Researcher Jerome Horwitz at the Michigan Cancer Foundation developed it as a potential cancer treatment by chemically-modifying thymine, a DNA building block. Subscribe to Asimov Press! Always free.

Clinical Trials 76

Clinical Trials Virus Vaccine DNA 76