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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

Disease 124
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Gianluca Pirozzi, MD, PhD, Celebrated for Dedication to the Field of Immunology and Rare Disease Research

The Pharma Data

Dr. Pirozzi received a Doctorate of Medicine from Università Campus Bio-Medico di Roma in Italy, a Doctorate of Philosophy in Immunology from Sapienza Università di Roma in Italy, a Post-Doctorate degree in Immunology from the Institut Pasteur in Paris, France, and business training at the London Business School, UK.

Disease 52
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US states seek $26.4 billion from major pharmaceutical manufacturers and distributors to settle opioid litigation

The Pharma Data

The lawsuit accused the companies of insurance fraud and for downplaying the risks of their opioid painkillers to both doctors and patients. It also helped draft letters to allow doctors to prescribe more of its drugs, and accused Allergan of misrepresenting the safety of its opioids, despite a 2010 FDA warning over its painkiller Kadian. .

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It Finally Happened – FDA’s OPDP Issues First Letter of 2023

Eye on FDA

The latest letter was issued for a website that promoted a treatment for hypercortisolemia in patients with Cushings Disease. It was the second letter for this company, the first having been issued in August, 2020 for a TV advertisement. Of those without boxed warnings (9 in number), only 2 had Warning Letters.

FDA 82
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Not all neoantigens are created equal

Drug Target Review

Patients with high numbers of clonal neoantigens show improved disease-free survival. Sergio holds a PhD from Dartmouth Medical School and from 2004 to 2010 he held a post-doctoral position at Memorial Sloan-Kettering Cancer Center.

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Discovering an Antimalarial Drug in Mao’s China

Codon

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In this light, scouring old Chinese remedies for new treatments for a disease specifically troublesome during war was entirely intuitive for Chinese biomedical scientists like Tu Youyou in the mid-20th century.

Drugs 130
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Deliberate Dysentery

Codon

Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops. How are disease targets selected for challenge trials?

Vaccine 111