Remove 2010 Remove Disease Remove Immune Response
article thumbnail

CAR-NK cells: promising for cancer therapy

Drug Target Review

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

Therapies 118
article thumbnail

Gamma delta T cells: a rising star in cancer therapy

Drug Target Review

Prior to that, Mr Ho was at New Leaf Venture Partners, a leading healthcare venture capital firm, where he launched and managed the public investments and cross-over portfolio, and served as its Public Investment Director from 2010 to 2014. Human γδ TCR repertoires in health and disease. References Fichtner A, Ravens S, Prinz I.

Therapies 105
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

GSK presents pivotal data at ESPID confirming effectiveness of its 5-in-1 meningococcal ABCWY vaccine candidate, with demonstrated coverage against a panel of 110 MenB strains

The Pharma Data

The preliminary data were disclosed at the 41st Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID) in Lisbon, Portugal. Five Neisseria meningitidis serogroups (A, B, C, W, and Y) account for nearly all invasive meningococcal disease (IMD) cases in most of the world.

Vaccine 40
article thumbnail

FDA Authorizes Phase 1 Trial of ImmunityBio’s Novel COVID-19 Vaccine Candidate hAd5; Dual Construct is Designed to Drive Both T Cell and Antibody Immunity

The Pharma Data

Additionally, immunogenicity, duration of immune response and occurrence of symptomatic COVID-19 will be measured. is a late-clinical-stage immunotherapy company developing next-generation therapies that drive immunogenic mechanisms for defeating cancers and infectious diseases. 2010 Jul;59(7):1131-5.

Vaccine 40
article thumbnail

Not all neoantigens are created equal

Drug Target Review

These neoantigens are identified by T cells of the immune system as foreign proteins and thus trigger an immune response. Neoantigens are recognised as non-self and trigger an immune response. Patients with high numbers of clonal neoantigens show improved disease-free survival.

article thumbnail

AvantGen Announces Licensing of Its Anti-SARS-CoV-2 Antibodies to IGM Biosciences for COVID-19 Therapy Development

The Pharma Data

In a recognized animal model of SARS-CoV-2 infection, AvantGen’s lead candidate antibody has been shown to significantly reduce viral load in, and macrophage infiltration of, the lungs, as well as reduce disease severity. These findings have been published in Frontiers in Immunology ( [link] ). About IGM Biosciences, Inc.

article thumbnail

Codon Digest: Seeing Colors After Gene Therapy

Codon

CNGA3-achromatopsia is a hereditary disease that causes people to see in shades of gray. Their cone cells, which are responsible for color vision, don’t work like normal. They’re talking about a patient who has a rare genetic disease. a lower risk of immune responses. From Sulis D.B. in Science.