Drug Target Review

JULY 5, 2023

After binding, the transposase enzyme will excise the flanked section of DNA (termed the transposon) and insert it into sites in the genome at specific target sequences. An example of the former includes a report in the journal Nature of a new tool that can increase the amount of DNA that can be inserted using CRISPR-Cas9 technology.

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Engineering DNA Laboratories Production 105

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

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Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

PLOS: DNA Science

JUNE 13, 2024

Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. The Likely Predecessor of SARS-CoV-2 – From my Past Blog Posts I wrote 100+ DNA Science blog posts during the pandemic about the virus. Or all at once?

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Virus RNA DNA Science 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Drug Target Review

AUGUST 9, 2023

The specific proteins found in these aggregates can vary, but approximately 95 percent of ALS patients and 50 percent of FTD patients develop aggregates containing the TDP-43 protein (short for tar DNA binding protein 43). 14 TDP-43 is a DNA and RNA binding protein that regulates the expression and splicing of several target transcripts.

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RNA Regulations Disease DNA 98

Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

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DNA Engineering Therapies RNA 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Therapies RNA DNA Engineering 52

The Pharma Data

JANUARY 24, 2021

Pamer joined the University of Chicago from Memorial Sloan Kettering Cancer Center in New York City, where he served as head of the Division of Subspecialty Medicine from 2011 to 2018 and director of the Center for Microbes, Inflammation and Cancer from 2010 to 2019.

Research 40

Research Bioinformatics Laboratories International 40

The Pharma Data

NOVEMBER 22, 2021

Important discoveries have included Francis Crick and James Watson’s DNA advance in 1953, and Professor Sir John Gurdon’s work on stem cells in 2012. Over the once century, roughly 50 Nobel Prize winners in chemistry and physiology or drug have been associated with Cambridge. region in the US, and Gothenburg in Sweden.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

Codon

JUNE 18, 2024

Right) The passage of text from a 2010 review that inspired Mikhail Shapiro to engineer gas vesicles. Voigt, Biotechnology Journal (2010). In 2010, Shapiro picked up a review article and noticed two short paragraphs —included almost as an afterthought—about gas vesicles. 31,500x magnification. Walsby , 1994 & M.

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Engineering Laboratories International Clinical Trials 70

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. This was the founding ethos of Moderna, the mRNA vaccine developer, when it was launched in 2010 by Noubar Afeyan and Doug Cole at Flagship Pioneering. “It was about 6 p.m.

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Engineering Vaccine Production RNA 87

The Pharma Data

SEPTEMBER 1, 2020

In general, antigen tests have a high specificity, though are not as sensitive as molecular tests that amplify the target viral DNA or RNA sequence in order to generate a quantifiable signal to indicate the presence of the virus in a sample.

Virus 52

Virus Laboratories Clinical Trials Treatment 52

Codon

FEBRUARY 27, 2024

In 2010, seven members of a soccer team in Oregon were infected with norovirus after touching a reusable grocery bag, which was covered in viral particles, and then eating the food inside. It renders proteins non-functional, inactivates key enzymes, damages DNA, and causes cells and viruses to break apart. million people in 2019.

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Virus Hospitals Production Regulations 73

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., Oct 1 5;24(20):2303-16, 2010; Blazek et al., 13, 261-91, 1997). Genes Dev.Oct 15;25(20):2158-72, 2011). Cancer Res.

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Production DNA RNA Regulations 62

New Drug Approvals

APRIL 18, 2023

significantly reduces the number of metastatic lung nodules in mice, and lowers the expression of human Alu DNA in mice, without body weight loss [2]. 2010 Apr 22;53(8):3376-88. They are for reference only. In Vivo Mavorixafor (AMD-070) (2 mg/kg, p.o.) MCE has not independently confirmed the accuracy of these methods. Skerlj RT, et al.

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Clinical Trials Virus Small Molecule Trials 52

Codon

JANUARY 2, 2024

“Hazards of Mouth Pipetting” The micropipette, an instrument favored by researchers around the world to measure and move liquids from one container to another and used for everything from forensic analysis to DNA sequencing, was invented by an obscure, 32-year-old German postdoc after a particularly productive two-day tantrum.

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Laboratories DNA Licensing Licensing 122

Agency IQ

MARCH 29, 2024

December 2023 Water System Restructuring Assessment Rule (Proposed Rule Stage) 2040-AF96 This rulemaking is mandated under the America’s Water Infrastructure Act (AWIA), which became law on October 23, 2018.

Regulations 40

Regulations Compliance Production Government 40

FDA Law Blog: Biosimilars

OCTOBER 24, 2024

By 2010, about 2000 isolated human genes had been patented in the U.S. In 2010, the Association for Molecular Pathology (AMP), among other organizations, brought suit against Myriad Genetics, challenging the validity of the company’s patents on the BRCA 1/2 genes. animal, viral, bacterial) DNA and RNA sequences.

Laboratories 64

Laboratories DNA Testimonials Production 64

Codon

FEBRUARY 16, 2025

Building a Circuit Much like electronic circuits, which use wires and transistors to create or process signals, a synthetic gene circuit is a network of biological parts — DNA, RNA, and proteins — that process inputs and generate outputs. Elowitz inserted his assembled DNA into E. 3 Subscribe to Asimov Press.

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DNA RNA Engineering Small Molecule 80

Codon

MARCH 16, 2025

I didn’t learn about them until the summer of 2010, when in examining my motivations to pursue a career in biomedical research, I started looking for explanations behind my mother’s disease. Today, decades after the invention of DNA sequencing, it is easy to take the accessibility of genomic data for granted.

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DNA Disease Medical Schools Hospitals 114

Codon

AUGUST 10, 2023

Nature Reviews Genetics (2010). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Nucleic Acids Research (2010).

DNA 97

DNA Cell Biology Molecular Biology Engineering 97

Codon

AUGUST 10, 2023

Nature Reviews Genetics (2010). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Nucleic Acids Research (2010).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

FEBRUARY 9, 2025

In 2010, grants from the NIH helped launch the Human Connectome Project (HCP) , a five-year effort aimed at mapping the structural and functional connectivity of the human brain using non-invasive techniques such as diffusion MRI (dMRI) and functional MRI (fMRI).

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Research Disease Engineering Regulations 100

Codon

FEBRUARY 23, 2025

Countries supported by PEPFAR saw HIV cases drop by 52 percent in 2023 compared to 2010, outpacing the 39 percent global decline. Researcher Jerome Horwitz at the Michigan Cancer Foundation developed it as a potential cancer treatment by chemically-modifying thymine, a DNA building block. million people.

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Clinical Trials Virus Vaccine DNA 68