Remove 2010 Remove Doctors Remove Regulations
article thumbnail

Mediating BRAF-mutant melanoma resistance

Drug Target Review

Our data demonstrate that the CoREST complex is a critical mediator of the distinct melanoma phenotypes, working through the regulation of both the phenotype-defining genes MITF and AXL as well as the master regulators of epithelial-to-mesenchymal transitions (EMT) and phenotype switching in melanoma and other cancers, SNAIL/SLUG/ZEB1/ZEB2.

article thumbnail

State Boards of Pharmacy Missing in Action During Opioid Crisis

Policy Prescription

state boards of pharmacy to properly regulate pharmacies that irresponsibly and too often illegally profited from opioid drug sales to patients. Arguably, that period represented the worst surge in opioid addiction to prescription drugs, when doctors were still flagrantly writing opioid prescriptions for patients with only moderate pain.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

The art and science of drug formulation

Drug Target Review

Global efforts to standardise regulations could streamline development processes and eventually improve the likelihood of drug development success. She began her career as a clinical oncologist before completing doctoral and post-doctoral training in carcinogenesis and tumour biology. References Allen, L. Popovich, N.

Science 59
article thumbnail

Genomics/Biobanks/Cohort Studies

Broad Institute

Known to be a regulator of metabolism, we have found that in addition it has profound behavioral effects in animals and humans, even evident in population-level economic behavior. The Sabatini Lab focuses on the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.

article thumbnail

Diabetes Smarts – Helping Men & Women To Prevent & Fight Diabetes Symptoms

The Pharma Data

Description: In this 8 Episode Diabetes-Fighting Series, I get to meet several doctors, nutritionists, current and former diabetics, from the around the world. As you read the book you will learn the signs and symptoms, the complications, and how a doctor diagnoses and monitors and treats patients with type 2 diabetes.

Doctors 52
article thumbnail

Deliberate Dysentery

Codon

The European Medicines Agency (EMA) is similar in this regard, although interestingly, that’s not the case in the United Kingdom, where regulators are not so directly involved in assessing a challenge study beforehand. The challenge agent also has to be produced under very stringent protocols.

Vaccine 117
article thumbnail

A Question 30 Years in the Making: Would a Final LDT Rule Withstand Judicial Scrutiny?

FDA Law Blog: Biosimilars

Lenz, Principal Medical Device Regulation Expert & Sophia R. Gibbs — For more than three decades, FDA has claimed that the Federal Food, Drug & Cosmetic (FD&C Act) gives the agency legal authority to regulate laboratory developed tests (LDTs) as medical devices (see our prior post here ). Gaulkin & Jeffrey N.