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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

“This could potentially help with disease prevention — if we know from someone’s retinal image that they are at high risk of developing glaucoma or cardiovascular disease in the future, we could refer them for follow-up screening or preventative treatment.”

Disease 124
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It Finally Happened – FDA’s OPDP Issues First Letter of 2023

Eye on FDA

The latest letter was issued for a website that promoted a treatment for hypercortisolemia in patients with Cushings Disease. It was the second letter for this company, the first having been issued in August, 2020 for a TV advertisement. Of those without boxed warnings (9 in number), only 2 had Warning Letters.

FDA 82
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Discovering an Antimalarial Drug in Mao’s China

Codon

In response to the precipitous rise in incidence, governments on both sides of the Pacific began a systematized search for antimalarial treatments. Over the course of 12 years, the Walter Reed Army Institute of Research (WRAIR) screened more than 250,000 compounds in search of an efficacious treatment. Nobody had an answer.

Drugs 130
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AHA News: Hospice Candidate at 2, She’s Now 13 and Thriving

The Pharma Data

” That was the term the doctors used six months after a third surgery to correct a heart defect that left her struggling to breathe while her lungs continued to fill with fluid. A doctor suggested hospice. Several doctors came in to evaluate what they were seeing. In March 2010, doctors did just that.

Doctors 52
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Mediating BRAF-mutant melanoma resistance

Drug Target Review

Rather than solely identifying tumour-associated mutations which can be specifically targeted for effective treatment, we now need to consider how non-mutational events play into both the development of the primary tumour and the development of therapy resistance.

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The art and science of drug formulation

Drug Target Review

Inhalers are useful in respiratory conditions, whereas topical treatments can be applied directly to the skin for localised treatment. Developing the correct formulation for these treatments will be key to ensure they are effective. For other compounds, it can be beneficial to target the drug more precisely to the affected area.

Science 59
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Deliberate Dysentery

Codon

yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying pathogenesis, the process by which a disease develops. Scientists studied black men infected with syphilis for several decades while withholding known treatments. You can do a challenge trial with deadly diseases, but you need a “rescue therapy.”

Vaccine 111